WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406667
CAS#: 303727-31-3
Description: L-779450 is a potent, selective and ATP-competitive Raf kinase inhibitor (IC50 = 10 nM). L-779450 suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.
MedKoo Cat#: 406667
Name: L-779450
CAS#: 303727-31-3
Chemical Formula: C20H14ClN3O
Exact Mass: 347.08254
Molecular Weight: 347.8
Elemental Analysis: C, 69.07; H, 4.06; Cl, 10.19; N, 12.08; O, 4.60
Synonym: L779450; L-779450; L 779450; L779,450; L 779,450; L-779,450.
IUPAC/Chemical Name: 2-chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol
InChi Key: WXJLXRNWMLWVFB-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)
SMILES Code: OC1=CC(C2=C(C3=CC=NC=C3)NC(C4=CC=CC=C4)=N2)=CC=C1Cl
1: Geserick P, Herlyn M, Leverkus M. On the TRAIL to overcome BRAF-inhibitor resistance. J Invest Dermatol. 2014 Feb;134(2):315-8. doi: 10.1038/jid.2013.348. PubMed PMID: 24424456.
2: Berger A, Quast SA, Plötz M, Kuhn NF, Trefzer U, Eberle J. RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells. J Invest Dermatol. 2014 Feb;134(2):430-40. doi: 10.1038/jid.2013.347. Epub 2013 Aug 16. PubMed PMID: 23955071.
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