Ac-FLTD-CMK | CAS# 2376255-48-8 | pyroptosis inhibitor

Ac-FLTD-CMK
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 471057

CAS#: 2376255-48-8

Description: Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4. Ac-FLTD-CMK administration significantly downregulated caspase-1 p20, caspase-11 p20, GSDMD N-terminal, IL-1β, and IL-18 expression; reduced LDH release; alleviated neuronal death; attenuated brain edema and blood-brain barrier damage; and improved neurobehavioral function in mice following traumatic brain injury.

Chemical Structure

Ac-FLTD-CMK

CAS# 2376255-48-8

Instruction

Theoretical Analysis

MedKoo Cat#: 471057
Name: Ac-FLTD-CMK
CAS#: 2376255-48-8
Chemical Formula: C26H37ClN4O8
Exact Mass: 568.23
Molecular Weight: 569.050
Elemental Analysis: C, 54.88; H, 6.55; Cl, 6.23; N, 9.85; O, 22.49

Price and Availability

Size	Price	Availability
50mg	USD 2350	2 Weeks
100mg	USD 3350	2 Weeks
200mg	USD 4350	2 Weeks
500mg	USD 6950	2 Weeks
1g	USD 8950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 2376255-48-8;

Synonym: Ac-FLTD-CMK

IUPAC/Chemical Name: (4S,7S,10S,13S)-4-benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

InChi Key: UCWNTWGHVCSMJP-WPUDHWPRSA-N

InChi Code: InChI=1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1

SMILES Code: O=C([C@@H](NC(C)=O)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)[C@@H](C)O)=O)CC(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 569.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Burdette BE, Esparza AN, Zhu H, Wang S. Gasdermin D in pyroptosis. Acta Pharm Sin B. 2021 Sep;11(9):2768-2782. doi: 10.1016/j.apsb.2021.02.006. Epub 2021 Apr 28. PMID: 34589396; PMCID: PMC8463274.

2: Wang P, Pan B, Tian J, Yang L, Chen Z, Yang L, Fan Z. Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury. Neuroreport. 2021 Feb 3;32(3):188-197. doi: 10.1097/WNR.0000000000001580. PMID: 33470761.

3: Li N, Wang Y, Wang X, Sun N, Gong YH. Pathway network of pyroptosis and its potential inhibitors in acute kidney injury. Pharmacol Res. 2022 Jan;175:106033. doi: 10.1016/j.phrs.2021.106033. Epub 2021 Dec 14. PMID: 34915124.

4: Cao H, Liang J, Liu J, He Y, Ke Y, Sun Y, Jiang S, Lin J. Novel Effects of Combination Therapy Through Inhibition of Caspase-1/Gasdermin D Induced- Pyroptosis in Lupus Nephritis. Front Immunol. 2021 Nov 19;12:720877. doi: 10.3389/fimmu.2021.720877. PMID: 34867948; PMCID: PMC8639704.

5: Tian XX, Li R, Liu C, Liu F, Yang LJ, Wang SP, Wang CL. NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation. Int Endod J. 2021 Jun;54(6):916-925. doi: 10.1111/iej.13469. Epub 2021 Jan 20. PMID: 33377178.

6: Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797. doi: 10.1073/pnas.1800562115. Epub 2018 Jun 11. PMID: 29891674; PMCID: PMC6042100.

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