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MedKoo CAT#: 471057

CAS#: 2376255-48-8

Description: Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4. Ac-FLTD-CMK administration significantly downregulated caspase-1 p20, caspase-11 p20, GSDMD N-terminal, IL-1β, and IL-18 expression; reduced LDH release; alleviated neuronal death; attenuated brain edema and blood-brain barrier damage; and improved neurobehavioral function in mice following traumatic brain injury.

Chemical Structure

CAS# 2376255-48-8

Theoretical Analysis

MedKoo Cat#: 471057
CAS#: 2376255-48-8
Chemical Formula: C26H37ClN4O8
Exact Mass: 568.23
Molecular Weight: 569.05
Elemental Analysis: C, 54.88; H, 6.55; Cl, 6.23; N, 9.85; O, 22.49

Price and Availability

Size Price Availability Quantity
50.0mg USD 2350.0 2 Weeks
100.0mg USD 3350.0 2 Weeks
200.0mg USD 4350.0 2 Weeks
500.0mg USD 6950.0 2 Weeks
1.0g USD 8950.0 2 Weeks
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Related CAS #: 2376255-48-8;  

Synonym: Ac-FLTD-CMK

IUPAC/Chemical Name: (4S,7S,10S,13S)-4-benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid


InChi Code: InChI=1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1

SMILES Code: O=C([C@@H](NC(C)=O)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)[C@@H](C)O)=O)CC(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 569.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Burdette BE, Esparza AN, Zhu H, Wang S. Gasdermin D in pyroptosis. Acta Pharm Sin B. 2021 Sep;11(9):2768-2782. doi: 10.1016/j.apsb.2021.02.006. Epub 2021 Apr 28. PMID: 34589396; PMCID: PMC8463274.

2: Wang P, Pan B, Tian J, Yang L, Chen Z, Yang L, Fan Z. Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury. Neuroreport. 2021 Feb 3;32(3):188-197. doi: 10.1097/WNR.0000000000001580. PMID: 33470761.

3: Li N, Wang Y, Wang X, Sun N, Gong YH. Pathway network of pyroptosis and its potential inhibitors in acute kidney injury. Pharmacol Res. 2022 Jan;175:106033. doi: 10.1016/j.phrs.2021.106033. Epub 2021 Dec 14. PMID: 34915124.

4: Cao H, Liang J, Liu J, He Y, Ke Y, Sun Y, Jiang S, Lin J. Novel Effects of Combination Therapy Through Inhibition of Caspase-1/Gasdermin D Induced- Pyroptosis in Lupus Nephritis. Front Immunol. 2021 Nov 19;12:720877. doi: 10.3389/fimmu.2021.720877. PMID: 34867948; PMCID: PMC8639704.

5: Tian XX, Li R, Liu C, Liu F, Yang LJ, Wang SP, Wang CL. NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation. Int Endod J. 2021 Jun;54(6):916-925. doi: 10.1111/iej.13469. Epub 2021 Jan 20. PMID: 33377178.

6: Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797. doi: 10.1073/pnas.1800562115. Epub 2018 Jun 11. PMID: 29891674; PMCID: PMC6042100.