WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465577
Description: W-105 is an antitumor agent. W-105 possessed excellent antiproliferative efficacy. W-105 could also apparently prevent the migration of hepatoma cells in a dose-dependent manner, indicating that W-105 had the potential to inhibit tumor metastasis. W-105 mainly blocked HepG2 cells in the G0/G1 phase, which was similar to the mechanism of its parent structure β-elemene. The IC50 value of W-105 against HepG2 cells is 6.107 μM.
MedKoo Cat#: 465577
Chemical Formula: C34H40N6O2
Exact Mass: 564.3213
Molecular Weight: 564.734
Elemental Analysis: C, 72.31; H, 7.14; N, 14.88; O, 5.67
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: W-105; W105; W 105;
IUPAC/Chemical Name: 2-((1-(2-((1S,3R,4R)-4-methyl-3-(prop-1-en-2-yl)-4-vinylcyclohexyl)allyl)-1H-1,2,3-triazol-4-yl)methyl)-6-(piperazin-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
InChi Key: BDHUBICXFAIOFR-SRYFTIFFSA-N
InChi Code: InChI=1S/C34H40N6O2/c1-6-34(5)13-12-24(18-29(34)22(2)3)23(4)19-39-20-25(36-37-39)21-40-32(41)27-9-7-8-26-30(38-16-14-35-15-17-38)11-10-28(31(26)27)33(40)42/h6-11,20,24,29,35H,1-2,4,12-19,21H2,3,5H3/t24-,29+,34-/m0/s1
SMILES Code: C=C([C@H]1CC[C@](C)(C=C)[C@@H](C(C)=C)C1)CN2C=C(CN3C(C4=CC=C(C5=CC=CC(C3=O)=C54)N6CCNCC6)=O)N=N2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 564.734 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang M, Li Z, Liu F, Yi Q, Pu C, Li Y, Luo T, Liang J, Wang J. Development of Asialoglycoprotein-Mediated Hepatocyte-Targeting Antitumor Prodrugs Triggered by Glutathione. J Med Chem. 2021 Oct 1. doi: 10.1021/acs.jmedchem.1c01365. Epub ahead of print. PMID: 34595917.