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MedKoo CAT#: 465577

CAS#: unknown

Description: W-105 is an antitumor agent. W-105 possessed excellent antiproliferative efficacy. W-105 could also apparently prevent the migration of hepatoma cells in a dose-dependent manner, indicating that W-105 had the potential to inhibit tumor metastasis. W-105 mainly blocked HepG2 cells in the G0/G1 phase, which was similar to the mechanism of its parent structure β-elemene. The IC50 value of W-105 against HepG2 cells is 6.107 μM.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 465577
Name: W-105
CAS#: unknown
Chemical Formula: C34H40N6O2
Exact Mass: 564.32
Molecular Weight: 564.734
Elemental Analysis: C, 72.31; H, 7.14; N, 14.88; O, 5.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: W-105; W105; W 105;

IUPAC/Chemical Name: 2-((1-(2-((1S,3R,4R)-4-methyl-3-(prop-1-en-2-yl)-4-vinylcyclohexyl)allyl)-1H-1,2,3-triazol-4-yl)methyl)-6-(piperazin-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione


InChi Code: InChI=1S/C34H40N6O2/c1-6-34(5)13-12-24(18-29(34)22(2)3)23(4)19-39-20-25(36-37-39)21-40-32(41)27-9-7-8-26-30(38-16-14-35-15-17-38)11-10-28(31(26)27)33(40)42/h6-11,20,24,29,35H,1-2,4,12-19,21H2,3,5H3/t24-,29+,34-/m0/s1

SMILES Code: C=C([C@H]1CC[C@](C)(C=C)[C@@H](C(C)=C)C1)CN2C=C(CN3C(C4=CC=C(C5=CC=CC(C3=O)=C54)N6CCNCC6)=O)N=N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 564.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang M, Li Z, Liu F, Yi Q, Pu C, Li Y, Luo T, Liang J, Wang J. Development of Asialoglycoprotein-Mediated Hepatocyte-Targeting Antitumor Prodrugs Triggered by Glutathione. J Med Chem. 2021 Oct 1. doi: 10.1021/acs.jmedchem.1c01365. Epub ahead of print. PMID: 34595917.