YS-370

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465572

CAS#: unknown

Description: YS-370 is P-gp inhibitor. YS-370 effectively reversed multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 bound directly to P-gp, did not alter expression or subcellular localization of P-gp in SW620/AD300 cells, but increased the intracellular accumulation of paclitaxel. Significantly, oral administration of YS-370 in combination with paclitaxel achieved much stronger antitumor activity in a xenograft model bearing SW620/Ad300 cells than either drug alone.

Chemical Structure

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YS-370
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465572
Name: YS-370
CAS#: unknown
Chemical Formula: C37H35BrN4O3
Exact Mass: 662.19
Molecular Weight: 663.616
Elemental Analysis: C, 66.97; H, 5.32; Br, 12.04; N, 8.44; O, 7.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: YS-370; YS370; YS 370;

IUPAC/Chemical Name: 4-(3-((4-(1-(2-bromobenzyl)-2-phenyl-1H-indol-3-yl)-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine

InChi Key: WSOJDUFWINGDJI-UHFFFAOYSA-N

InChi Code: InChI=1S/C37H35BrN4O3/c1-43-33-23-31-29(22-34(33)45-19-9-16-41-17-20-44-21-18-41)36(40-25-39-31)35-28-13-6-8-15-32(28)42(24-27-12-5-7-14-30(27)38)37(35)26-10-3-2-4-11-26/h2-8,10-15,22-23,25H,9,16-21,24H2,1H3

SMILES Code: BrC1=C(CN2C(C=CC=C3)=C3C(C4=NC=NC5=CC(OC)=C(OCCCN6CCOCC6)C=C45)=C2C7=CC=CC=C7)C=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 663.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yuan S, Wang B, Dai QQ, Zhang XN, Zhang JY, Zuo JH, Liu H, Chen ZS, Li GB, Wang S, Liu HM, Yu B. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021 Sep 21. doi: 10.1021/acs.jmedchem.1c01452. Epub ahead of print. PMID: 34546748.