AZD9496

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Description: AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell lines at picomolar concentrations. AZD9496 is curently under clinical trials. AZD9496 may be useful for the treatment of ER+ breast cancer.

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Chemical Structure

Theoretical Analysis

MedKoo Cat#: 206208
Name: AZD9496
CAS#: 1639042-08-2 (free base)
Chemical Formula: C25H25F3N2O2
Exact Mass: 442.18681
Molecular Weight: 442.48
Elemental Analysis: C, 67.86; H, 5.70; F, 12.88; N, 6.33; O, 7.23

Related CAS #: 1639042-08-2 (free base)   1639042-28-6 (maleate)    

Synonym: AZD9496; AZD-9496; AZD 9496.

IUPAC/Chemical Name: (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid

InChi Key: DFBDRVGWBHBJNR-BBNFHIFMSA-N

InChi Code: InChI=1S/C25H25F3N2O2/c1-14-10-17-16-6-4-5-7-20(16)29-23(17)24(30(14)13-25(2,3)28)22-18(26)11-15(12-19(22)27)8-9-21(31)32/h4-9,11-12,14,24,29H,10,13H2,1-3H3,(H,31,32)/b9-8+/t14-,24-/m1/s1

SMILES Code: O=C(O)/C=C/C1=CC(F)=C([C@H]2N(CC(C)(F)C)[C@H](C)CC3=C2NC4=C3C=CC=C4)C(F)=C1

Technical Data

Additional Information

 Related CAS#
CAS#1639042-08-2 ( AZD9496 free base)
CAS#1639042-28-6 ( AZD9496 maleate). 
 
 
 

References