Pyrvinium pamoate

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MedKoo CAT#: 415017

CAS#: 3546-41-6 (pamoate)

Description: Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. Pyrvinium was identified as a potent Wnt inhibitor, acting through activation of Casein kinase CK1α. Pyrvinium salts can also inhibit the growth of cancer cells.[6] More specifically, the pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation.

Chemical Structure

Pyrvinium pamoate
CAS# 3546-41-6 (pamoate)

Theoretical Analysis

MedKoo Cat#: 415017
Name: Pyrvinium pamoate
CAS#: 3546-41-6 (pamoate)
Chemical Formula: C75H72N6O62+
Exact Mass:
Molecular Weight: 1153.44
Elemental Analysis: C, 78.10; H, 6.29; N, 7.29; O, 8.32

Price and Availability

Size Price Availability Quantity
10.0mg USD 250.0 2 Weeks
50.0mg USD 400.0 2 Weeks
100.0mg USD 750.0 2 Weeks
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Related CAS #: 110-85-0 (cation)   142-88-1 (adipate)   3546-41-6 (pamoate); 548-84-5 (Cl)   35648-29-4 (Iodide)    

Synonym: Pyrvinium pamoate; Vipyrvinium embonate, Altolat, Alnoxin, Pamovin, Vermitibier; NSC 223622; NSC223622; NSC-223622; VPC-14337; VPC 14337; VPC14337;

IUPAC/Chemical Name: (E)-2-(2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)vinyl)-6-(dimethylamino)-1-methylquinolin-1-ium 4,4'-methylenebis(3-hydroxy-2-naphthoate)


InChi Code: InChI=1S/2C26H28N3.C23H16O6/c2*1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h2*6-18H,1-5H3;1-10,24-25H,11H2,(H,26,27)(H,28,29)/q2*+1;/p-2

SMILES Code: CN(C1=CC2=C(C=C1)[N+](C)=C(C=C2)/C=C/C3=C(N(C(C)=C3)C4=CC=CC=C4)C)C.CN(C5=CC6=C(C=C5)[N+](C)=C(C=C6)/C=C/C7=C(N(C(C)=C7)C8=CC=CC=C8)C)C.[O-]C(C9=CC%10=C(C(CC%11=C(C(C([O-])=O)=CC%12=C%11C=CC=C%12)O)=C9O)C=CC=C%10)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 1153.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Fisher MA, Jacobs DE, Hutchinson MJ, Dick IG. Studies on the control of Toxocara canis in breeding kennels. Vet Parasitol. 1994 Oct;55(1-2):87-92. PubMed PMID: 7886923.

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8: Sharma RK, Singh K, Saxena KK. Effect of parbendazole and piperazine adipate on the activity of some enzymes of Ascaridia galli and Heterakis gallinae. Vet Parasitol. 1987 May;24(3-4):211-20. PubMed PMID: 3617427.

9: Hennig UG, Galindo-Prince OC, Cortinas de Nava C, Savage EA, von Borstel RC. A comparison of the genetic activity of pyrvinium pamoate with that of several other anthelmintic drugs in Saccharomyces cerevisiae. Mutat Res. 1987 Feb;187(2):79-89. PubMed PMID: 3543669.

10: Grzywacz M. Integumentomuscular sac of Ascaris lumbricoides suis L: a biomembrane for studies on the transport of chemical substances. Pol J Pharmacol Pharm. 1986 Jul-Aug;38(4):335-41. PubMed PMID: 2430266.

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12: Glinka R, Grzywacz M, Kotełko B, Majchrzak M, Malinowski H, Mikołajewska H, Mikiciukolasik E, Szkukliński J. Investigations of anthelminthic activity and synthesis of new derivatives of perhydroazepine, perhydro-1,4-diazepine, perhydro-1,4-oxazepine and perhydro-1,5-oxazocine. Pol J Pharmacol Pharm. 1980 Sep-Oct;32(5):773-7. PubMed PMID: 7196575.

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15: Grzywacz M. Application of the isotope technique in pharmacodynamic analysis of penetration of drugs into parasites. Mater Med Pol. 1975 Oct-Dec;7(4):311-3. PubMed PMID: 1214519.

16: Rim HJ, Ha JH, Lee JS, Hyun I, Uh KB. Pyrantel embonate in mass treatment of ascariasis and comparison with piperazine adipate and santonin-kainic acid complex. Kisaengchunghak Chapchi. 1974 Dec;12(2):141-146. PubMed PMID: 12913476.

17: Jarnicka-Stanios H. [Usefulness of idalbin and piperazine adipate in the treatment of enterobiasis in children]. Wiad Lek. 1973 Feb 15;26(4):373-7. Polish. PubMed PMID: 4688826.

18: Vaidya AB, Ambani LM, Karandikar PV, Sheth UK. Piperazine adipate in tropical eosinophilia--a preliminary study. Indian J Med Sci. 1971 Oct;25(10):684-9. PubMed PMID: 4943620.

19: Kühn W, Buchwalder R, Gräfner G, Hiepe T. [Drug control of eelworm in the domestic chicken, using piperazine adipate, with special reference to laying performance]. Monatsh Veterinarmed. 1971 Jul 15;26(14):540-2. German. PubMed PMID: 5131926.

20: Kühn W, Buchwalder R, Gräfner G, Hiepe T. [Control of ascriasis in the domestic fowl by use of piperazine adipate--with special reference to laying performance]. Monatsh Veterinarmed. 1971 Jul;26(14):540-2. German. PubMed PMID: 5113708.