WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 415003
CAS#: 7009-68-9 (free base)
Description: Pyroxamine Free Base is an antihistamine and anticholinergic related to diphenylpyraline.
MedKoo Cat#: 415003
Name: Pyroxamine Free Base
CAS#: 7009-68-9 (free base)
Chemical Formula: C18H20ClNO
Exact Mass: 301.1233
Molecular Weight: 301.81
Elemental Analysis: C, 71.63; H, 6.68; Cl, 11.75; N, 4.64; O, 5.30
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 7009-68-9 (free base); 5560-75-8 (maleate)
Synonym: Pyroxamine Free Base; BRN0260129; BRN-0260129; BRN 0260129
IUPAC/Chemical Name: Pyrrolidine, 3-(p-chloro-alpha-phenylbenzyloxy)-1-methyl-
InChi Key: CMARNPIDSNAMJM-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H20ClNO/c1-20-12-11-17(13-20)21-18(14-5-3-2-4-6-14)15-7-9-16(19)10-8-15/h2-10,17-18H,11-13H2,1H3
SMILES Code: CN1CC(OC(C2=CC=CC=C2)C3=CC=C(Cl)C=C3)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 301.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: THOMAS JW. Pyroxamine: a clinical study of a new antihistamine. Ann Allergy. 1961 Jul;19:760-5. PMID: 13776501.
2: Smits PH, De Haan M, Maat C, Grivell LA. The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene. Yeast. 1994 Apr;10 Suppl A:S75-80. doi: 10.1002/yea.320100010. PMID: 8091864.
