Pirenzepine free base
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MedKoo CAT#: 414991

CAS#: 28797-61-7 (free base)

Description: Pirenzepine is an antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

Chemical Structure

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Pirenzepine free base
CAS# 28797-61-7 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 414991
Name: Pirenzepine free base
CAS#: 28797-61-7 (free base)
Chemical Formula: C19H21N5O2
Exact Mass: 351.17
Molecular Weight: 351.410
Elemental Analysis: C, 64.94; H, 6.02; N, 19.93; O, 9.11

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
100mg USD 1350 2 Weeks
1g USD 4250 2 Weeks
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Related CAS #: 28797-61-7 (free base)   29868-97-1 (2HCl)   84827-28-1 (hydrate)   93173-05-8 (HCl)    

Synonym: Pirenzepine free base; Pirenzepin;

IUPAC/Chemical Name: 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-

InChi Key: RMHMFHUVIITRHF-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)

SMILES Code: O=C1NC2=CC=CN=C2N(C(CN3CCN(C)CC3)=O)C4=CC=CC=C14

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 351.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Callaghan JT, Bergstrom RF, Ptak LR, Beasley CM. Olanzapine. Pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet. 1999 Sep;37(3):177-93. doi: 10.2165/00003088-199937030-00001. PMID: 10511917.

2: Del Tacca M, Danesi R, Blandizzi C, Bernardini MC. Un antimuscarinico selettivo: la pirenzepina. Rassegna delle sue proprietà farmacologiche e cliniche [A selective antimuscarinic agent: pirenzepine. Review of its pharmacologic and clinical properties]. Minerva Dietol Gastroenterol. 1989 Jul- Sep;35(3):175-89. Italian. PMID: 2574837.

3: Leech EM, Cottriall CL, McBrien NA. Pirenzepine prevents form deprivation myopia in a dose dependent manner. Ophthalmic Physiol Opt. 1995 Sep;15(5):351-6. PMID: 8524553.

4: Smith PM, Troughton AH, Gleeson F, Walters J, McCarthy CF. Pirenzepine in non-ulcer dyspepsia: a double-blind multicentre trial. J Int Med Res. 1990 Jan- Feb;18(1):16-20. doi: 10.1177/030006059001800103. PMID: 2185962.

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7: Kerwin R. Olanzapine. Lancet. 1997 Aug 23;350(9077):594. doi: 10.1016/S0140-6736(05)63186-8. PMID: 9284804.

8: Tu J, Pang H, Yan Z, Li P. Ocular permeability of pirenzepine hydrochloride enhanced by methoxy poly(ethylene glycol)-poly(D, L-lactide) block copolymer. Drug Dev Ind Pharm. 2007 Oct;33(10):1142-50. doi: 10.1080/03639040701397381. PMID: 17852364.

9: Bustos-Fernández L, González E, Kofoed JA, Hamamura S, Schiffrin E, Celener D, Ledesma de Paolo MI. Pirenzepine as anti-inflammatory drug in a model of experimental colitis in rat. Acta Physiol Pharmacol Latinoam. 1987;37(4):415-22. PMID: 3274021.

10: Hunter AJ, Roberts FF. The effect of pirenzepine on spatial learning in the Morris Water Maze. Pharmacol Biochem Behav. 1988 Jun;30(2):519-23. doi: 10.1016/0091-3057(88)90490-x. PMID: 3174783.