PF06447475
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406655

CAS#: 1527473-33-1

Description: PF06447475 is a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome-wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in the total population, gives rise to increased kinase activity. As such, LRRK2 kinase inhibitors are potentially useful in the treatment of PD.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 650
1g
USD 2650
Size
Price

25mg
USD 250
200mg
USD 850
2g
USD 3850
Size
Price

50mg
USD 450
500mg
USD 1350
5g
USD 6450

PF06447475, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 200mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406655
Name: PF06447475
CAS#: 1527473-33-1
Chemical Formula: C17H15N5O
Exact Mass: 305.12766
Molecular Weight: 305.33
Elemental Analysis: C, 66.87; H, 4.95; N, 22.94; O, 5.24


Synonym: PF06447475; PF-06447475; PF 06447475; PF6447475; PF-6447475; PF 6447475.

IUPAC/Chemical Name: 3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

InChi Key: BHTWDJBVZQBRKP-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)

SMILES Code: N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

 1: Henderson JL, Kormos BL, Hayward MM, Coffman KJ, Jasti J, Kurumbail RG, Wager  TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD, Galatsis P. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. doi: 10.1021/jm5014055. Epub 2014 Nov 17. PubMed PMID: 25353650.