WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465546

CAS#: unknown

Description: YWN-00640 is a novel inhibitor of PD-1/PD-L1 (IC50 value of 56.58 nM), dose-dependently promoting HepG2 cell death in a co-culture model of HepG2/hPD-L1 and Jurkat T cells, effectively inhibiting tumor growth (TGI of 76.4% at 90 mg/kg) in an immune checkpoint humanized mouse model with no obvious toxicity.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 465546
Name: YWN-00640
CAS#: unknown
Chemical Formula: C35H33ClF3NO5
Exact Mass: 639.1999
Molecular Weight: 640.0962
Elemental Analysis: C, 65.68; H, 5.20; Cl, 5.54; F, 8.90; N, 2.19; O, 12.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: YWN-00640; YWN00640; YWN 00640; PD-1/PD-L1 inhibitor CH1;

IUPAC/Chemical Name: (R)-1-(5-chloro-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)-2-((4-(trifluoromethoxy)benzyl)oxy)benzyl)piperidine-2-carboxylic acid


InChi Code: InChI=1S/C35H33ClF3NO5/c1-23-26(10-7-11-29(23)25-8-3-2-4-9-25)22-44-33-19-32(43-21-24-13-15-28(16-14-24)45-35(37,38)39)27(18-30(33)36)20-40-17-6-5-12-31(40)34(41)42/h2-4,7-11,13-16,18-19,31H,5-6,12,17,20-22H2,1H3,(H,41,42)/t31-/m1/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 640.0962 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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