M3258

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465513

CAS#: 2285330-15-4

Description: M3258 is a novel selective inhibitor of the immunoproteasome subunit LMP7 (β5i), delivering efficacy in multiple myeloma models.


Chemical Structure

img
M3258
CAS# 2285330-15-4

Theoretical Analysis

MedKoo Cat#: 465513
Name: M3258
CAS#: 2285330-15-4
Chemical Formula: C17H20BNO5
Exact Mass: 329.1435
Molecular Weight: 329.159
Elemental Analysis: C, 62.03; H, 6.12; B, 3.28; N, 4.26; O, 24.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: M3258; M 3258; M-3258;

IUPAC/Chemical Name: ((S)-2-(benzofuran-3-yl)-1-((1R,2R,4S)-7-oxabicyclo[2.2.1]heptane-2-carboxamido)ethyl)boronic acid

InChi Key: RFQDLTYXNINJON-KSZJFAHPSA-N

InChi Code: InChI=1S/C17H20BNO5/c20-17(13-8-11-5-6-15(13)24-11)19-16(18(21)22)7-10-9-23-14-4-2-1-3-12(10)14/h1-4,9,11,13,15-16,21-22H,5-8H2,(H,19,20)/t11-,13+,15+,16+/m0/s1

SMILES Code: O=C([C@H]1[C@@](O2)([H])CC[C@@]2([H])C1)N[C@@H](B(O)O)CC3=COC4=CC=CC=C34

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 329.159 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Sloot W, Glaser N, Hansen A, Hellmann J, Jaeckel S, Johannes S, Knippel A, Lai V, Onidi M. Improved nonclinical safety profile of a novel, highly selective inhibitor of the immunoproteasome subunit LMP7 (M3258). Toxicol Appl Pharmacol. 2021 Oct 15;429:115695. doi: 10.1016/j.taap.2021.115695. Epub 2021 Aug 20. PMID: 34419493.

2: Klein M, Busch M, Friese-Hamim M, Crosignani S, Fuchss T, Musil D, Rohdich F, Sanderson MP, Seenisamy J, Walter-Bausch G, Zanelli U, Hewitt P, Esdar C, Schadt O. Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i). J Med Chem. 2021 Jul 22;64(14):10230-10245. doi: 10.1021/acs.jmedchem.1c00604. Epub 2021 Jul 6. PMID: 34228444.

3: Sanderson MP, Friese-Hamim M, Walter-Bausch G, Busch M, Gaus S, Musil D, Rohdich F, Zanelli U, Downey-Kopyscinski SL, Mitsiades CS, Schadt O, Klein M, Esdar C. M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models. Mol Cancer Ther. 2021 Aug;20(8):1378-1387. doi: 10.1158/1535-7163.MCT-21-0005. Epub 2021 May 27. PMID: 34045234.

4: Jenkins TW, Downey-Kopyscinski SL, Fields JL, Rahme GJ, Colley WC, Israel MA, Maksimenko AV, Fiering SN, Kisselev AF. Activity of immunoproteasome inhibitor ONX-0914 in acute lymphoblastic leukemia expressing MLL-AF4 fusion protein. Sci Rep. 2021 May 25;11(1):10883. doi: 10.1038/s41598-021-90451-9. PMID: 34035431; PMCID: PMC8149845.