SS5020

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406648

CAS#: 1334310-70-1

Description: SS5020 is a a new benzopyran antiestrogen. Unlike tamoxifen (TAM), SS5020 exhibits no genotoxic activity to damage DNA. Furthermore, SS5020 does not present significant uterotrophic potential in rats; in contrast, the structurally related compounds, TAM, toremifene, raloxifene (RAL) and SP500263 all have uterotrophic activity. At the human equivalent molar dose of TAM (0.33 or 1.0 mg/kg), SS5020 had much stronger antitumor potential than those same antiestrogens against 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats.


Chemical Structure

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SS5020
CAS# 1334310-70-1

Theoretical Analysis

MedKoo Cat#: 406648
Name: SS5020
CAS#: 1334310-70-1
Chemical Formula: C25H18O5
Exact Mass: 398.11542
Molecular Weight: 398.41
Elemental Analysis: C, 75.37; H, 4.55; O, 20.08

Size Price Shipping out time Quantity
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Pricing updated 2021-03-01. Prices are subject to change without notice.

Optional 3: SS5020, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.

Synonym: SS5020; SS5020; SS 5020.

IUPAC/Chemical Name: (E)-3-(4-((7-hydroxy-2-oxo-3-phenyl-2H-chromen-4-yl)methyl)phenyl)acrylic acid

InChi Key: YGKGINZAHYHTNB-JLHYYAGUSA-N

InChi Code: InChI=1S/C25H18O5/c26-19-11-12-20-21(14-17-8-6-16(7-9-17)10-13-23(27)28)24(18-4-2-1-3-5-18)25(29)30-22(20)15-19/h1-13,15,26H,14H2,(H,27,28)/b13-10+

SMILES Code: O=C(O)/C=C/C1=CC=C(CC(C2=C(O3)C=C(O)C=C2)=C(C4=CC=CC=C4)C3=O)C=C1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 398.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Degorce SL, Bailey A, Callis R, De Savi C, Ducray R, Lamont G, MacFaul P, Maudet M, Martin S, Morgentin R, Norman RA, Peru A, Pink JH, Plé PA, Roberts B, Scott JS. Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic

Acids as Oral Selective Estrogen Receptor Down-Regulators. J Med Chem. 2015 Apr 1. [Epub ahead of print] PubMed PMID: 25790336.

2: Suzuki N, Liu X, Laxmi YR, Okamoto K, Kim HJ, Zhang G, Chen JJ, Okamoto Y, Shibutani S. Anti-breast cancer potential of SS5020, a novel benzopyran antiestrogen. Int J Cancer. 2011 Feb 15;128(4):974-82. doi: 10.1002/ijc.25659. Epub 2010 Oct 29. PubMed PMID: 20824696; PubMed Central PMCID: PMC3011858.

 

SS5020

10mg / Not available


Additional Information