WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406648
Description: SS5020 is a a new benzopyran antiestrogen. Unlike tamoxifen (TAM), SS5020 exhibits no genotoxic activity to damage DNA. Furthermore, SS5020 does not present significant uterotrophic potential in rats; in contrast, the structurally related compounds, TAM, toremifene, raloxifene (RAL) and SP500263 all have uterotrophic activity. At the human equivalent molar dose of TAM (0.33 or 1.0 mg/kg), SS5020 had much stronger antitumor potential than those same antiestrogens against 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats.
MedKoo Cat#: 406648
Chemical Formula: C25H18O5
Exact Mass: 398.11542
Molecular Weight: 398.41
Elemental Analysis: C, 75.37; H, 4.55; O, 20.08
Optional 3: SS5020, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.
Synonym: SS5020; SS5020; SS 5020.
IUPAC/Chemical Name: (E)-3-(4-((7-hydroxy-2-oxo-3-phenyl-2H-chromen-4-yl)methyl)phenyl)acrylic acid
InChi Key: YGKGINZAHYHTNB-JLHYYAGUSA-N
InChi Code: InChI=1S/C25H18O5/c26-19-11-12-20-21(14-17-8-6-16(7-9-17)10-13-23(27)28)24(18-4-2-1-3-5-18)25(29)30-22(20)15-19/h1-13,15,26H,14H2,(H,27,28)/b13-10+
SMILES Code: O=C(O)/C=C/C1=CC=C(CC(C2=C(O3)C=C(O)C=C2)=C(C4=CC=CC=C4)C3=O)C=C1
The following data is based on the product molecular weight 398.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Degorce SL, Bailey A, Callis R, De Savi C, Ducray R, Lamont G, MacFaul P, Maudet M, Martin S, Morgentin R, Norman RA, Peru A, Pink JH, PlÃ© PA, Roberts B, Scott JS. Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic
Acids as Oral Selective Estrogen Receptor Down-Regulators. J Med Chem. 2015 Apr 1. [Epub ahead of print] PubMed PMID: 25790336.
2: Suzuki N, Liu X, Laxmi YR, Okamoto K, Kim HJ, Zhang G, Chen JJ, Okamoto Y, Shibutani S. Anti-breast cancer potential of SS5020, a novel benzopyran antiestrogen. Int J Cancer. 2011 Feb 15;128(4):974-82. doi: 10.1002/ijc.25659. Epub 2010 Oct 29. PubMed PMID: 20824696; PubMed Central PMCID: PMC3011858.