CUN79177
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MedKoo CAT#: 556025

CAS#: 2270879-17-7

Description: NVP-RXI570, also known as CUN79177 and BRM/BRG1 ATP Inhibitor-1, is an orally Active Inhibitors (IC50=5 nM) of Brahma Homolog (BRM)​/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)​/SMARCA4-​Mutant Cancers. CUN79177 was first reported ion Journal of Medicinal Chemistry (2018), 61(22), 10155-10172. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

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CUN79177
CAS# 2270879-17-7
Instruction

Theoretical Analysis

MedKoo Cat#: 556025
Name: CUN79177
CAS#: 2270879-17-7
Chemical Formula: C11H9F3N4O2S
Exact Mass: 318.04
Molecular Weight: 318.274
Elemental Analysis: C, 41.51; H, 2.85; F, 17.91; N, 17.60; O, 10.05; S, 10.07

Price and Availability

Size Price Availability Quantity
100mg USD 2450 2 Weeks
200mg USD 3650 2 Weeks
500mg USD 4950 2 Weeks
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Synonym: BRM/BRG1 ATP Inhibitor-1; CUN79177; CUN79177; CUN-79177; NVP-RXI570; NVP-RXI-570; NVP-RXI 570;

IUPAC/Chemical Name: 1-[3-(Difluoromethyl)isothiazol-5-yl]-3-[2-fluoro-5-(hydroxymethyl)pyridin-4-yl]urea

InChi Key: CKYCAIAVJIFWPE-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)

SMILES Code: O=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 318.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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