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MedKoo CAT#: 406642
CAS#: 1665195-94-7
Description: BAZ2-ICR is an excellent chemical probe for functional studies of the BAZ2 bromodomains in vitro and in vivo. The bromodomain containing proteins BAZ2A/B play essential roles in chromatin remodeling and regulation of noncoding RNAs. BAZ2-ICR has IC50 (BAZ2A) = 130 nM; IC50(BAZ2B) = 180 nM; logD = 1.05; solubility 25 mM (D2O) and F = 70%.
MedKoo Cat#: 406642
Name: BAZ2-ICR
CAS#: 1665195-94-7
Chemical Formula: C20H19N7
Exact Mass: 357.17019
Molecular Weight: 357.41
Elemental Analysis: C, 67.21; H, 5.36; N, 27.43
Synonym: BAZ2-ICR; BAZ2ICR; BAZ2 ICR.
IUPAC/Chemical Name: 4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile
InChi Key: RRZVGDGTWNQAPW-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3
SMILES Code: CN(N=C1)C=C1C2=C(C3=CC=C(C#N)C=C3)N(CCC4=CN(C)N=C4)C=N2
1: Drouin L, McGrath S, Vidler LR, Chaikuad A, Monteiro O, Tallant C, Philpott M, Rogers C, Fedorov O, Liu M, Akhtar W, Hayes A, Raynaud F, Müller S, Knapp S, Hoelder S. Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9. doi: 10.1021/jm501963e. Epub 2015 Feb 26. PubMed PMID: 25719566.