WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406641
Description: AZD3147 is an extremely potent and selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 1.5 nM) with physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate.
MedKoo Cat#: 406641
Chemical Formula: C24H31N5O4S2
Exact Mass: 517.18175
Molecular Weight: 517.66
Elemental Analysis: C, 55.68; H, 6.04; N, 13.53; O, 12.36; S, 12.39
AZD3147, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: AZD3147; AZD-3147; AZD 3147.
IUPAC/Chemical Name: (S)-1-(4-(4-(1-(cyclopropylsulfonyl)cyclopropyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)thiourea
InChi Key: JWGVUDPAMQEIJU-INIZCTEOSA-N
InChi Code: InChI=1S/C24H31N5O4S2/c1-16-15-33-13-11-29(16)21-14-20(24(8-9-24)35(31,32)19-6-7-19)27-22(28-21)17-2-4-18(5-3-17)26-23(34)25-10-12-30/h2-5,14,16,19,30H,6-13,15H2,1H3,(H2,25,26,34)/t16-/m0/s1
SMILES Code: S=C(NCCO)NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=CC(C4(S(=O)(C5CC5)=O)CC4)=N2)C=C1
The following data is based on the product molecular weight 517.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Kurt G. Pike *, Jeff Morris , Linette Ruston , Sarah L. Pass , Ryan Greenwood , Emma J. Williams , Julie Demeritt , Janet D. Culshaw , Kristy Gill , Martin Pass , M. Raymond V. Finlay , Catherine J. Good , Craig A. Roberts , Gordon S. Currie , Kevin Blades , Jonathan M. Eden , and Stuart E. Pearson. Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2. J. Med. Chem., 2015, 58 (5), pp 2326Â–2349