WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406641
CAS#: 1101810-02-9
Description: AZD3147 is an extremely potent and selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 1.5 nM) with physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate.
MedKoo Cat#: 406641
Name: AZD3147
CAS#: 1101810-02-9
Chemical Formula: C24H31N5O4S2
Exact Mass: 517.18175
Molecular Weight: 517.66
Elemental Analysis: C, 55.68; H, 6.04; N, 13.53; O, 12.36; S, 12.39
Synonym: AZD3147; AZD-3147; AZD 3147.
IUPAC/Chemical Name: (S)-1-(4-(4-(1-(cyclopropylsulfonyl)cyclopropyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)thiourea
InChi Key: JWGVUDPAMQEIJU-INIZCTEOSA-N
InChi Code: InChI=1S/C24H31N5O4S2/c1-16-15-33-13-11-29(16)21-14-20(24(8-9-24)35(31,32)19-6-7-19)27-22(28-21)17-2-4-18(5-3-17)26-23(34)25-10-12-30/h2-5,14,16,19,30H,6-13,15H2,1H3,(H2,25,26,34)/t16-/m0/s1
SMILES Code: S=C(NCCO)NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=CC(C4(S(=O)(C5CC5)=O)CC4)=N2)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 517.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Kurt G. Pike *, Jeff Morris , Linette Ruston , Sarah L. Pass , Ryan Greenwood , Emma J. Williams , Julie Demeritt , Janet D. Culshaw , Kristy Gill , Martin Pass , M. Raymond V. Finlay , Catherine J. Good , Craig A. Roberts , Gordon S. Currie , Kevin Blades , Jonathan M. Eden , and Stuart E. Pearson. Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2. J. Med. Chem., 2015, 58 (5), pp 2326–2349
