AZD3147
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MedKoo CAT#: 406641

CAS#: 1101810-02-9

Description: AZD3147 is an extremely potent and selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 1.5 nM) with physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate.


Chemical Structure

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AZD3147
CAS# 1101810-02-9

Theoretical Analysis

MedKoo Cat#: 406641
Name: AZD3147
CAS#: 1101810-02-9
Chemical Formula: C24H31N5O4S2
Exact Mass: 517.18175
Molecular Weight: 517.66
Elemental Analysis: C, 55.68; H, 6.04; N, 13.53; O, 12.36; S, 12.39

Price and Availability

Size Price Availability Quantity
1.0mg USD 225.0 2 Weeks
5.0mg USD 455.0 2 Weeks
10.0mg USD 675.0 2 Weeks
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Synonym: AZD3147; AZD-3147; AZD 3147.

IUPAC/Chemical Name: (S)-1-(4-(4-(1-(cyclopropylsulfonyl)cyclopropyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)thiourea

InChi Key: JWGVUDPAMQEIJU-INIZCTEOSA-N

InChi Code: InChI=1S/C24H31N5O4S2/c1-16-15-33-13-11-29(16)21-14-20(24(8-9-24)35(31,32)19-6-7-19)27-22(28-21)17-2-4-18(5-3-17)26-23(34)25-10-12-30/h2-5,14,16,19,30H,6-13,15H2,1H3,(H2,25,26,34)/t16-/m0/s1

SMILES Code: S=C(NCCO)NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=CC(C4(S(=O)(C5CC5)=O)CC4)=N2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 517.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Kurt G. Pike *, Jeff Morris , Linette Ruston , Sarah L. Pass , Ryan Greenwood , Emma J. Williams , Julie Demeritt , Janet D. Culshaw , Kristy Gill , Martin Pass , M. Raymond V. Finlay , Catherine J. Good , Craig A. Roberts , Gordon S. Currie , Kevin Blades , Jonathan M. Eden , and Stuart E. Pearson. Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2. J. Med. Chem., 2015, 58 (5), pp 2326–2349

AZD3147

1.0mg / USD 225.0


Additional Information