AZD3147
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406641

CAS#: 1101810-02-9

Description: AZD3147 is an extremely potent and selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 1.5 nM) with physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate.

Chemical Structure

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AZD3147
CAS# 1101810-02-9
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 406641
Name: AZD3147
CAS#: 1101810-02-9
Chemical Formula: C24H31N5O4S2
Exact Mass: 517.18175
Molecular Weight: 517.66
Elemental Analysis: C, 55.68; H, 6.04; N, 13.53; O, 12.36; S, 12.39

Size Price Shipping out time Quantity
1mg USD 225 2 Weeks
5mg USD 455 2 Weeks
10mg USD 675 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-03-02. Prices are subject to change without notice.

AZD3147, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: AZD3147; AZD-3147; AZD 3147.

IUPAC/Chemical Name: (S)-1-(4-(4-(1-(cyclopropylsulfonyl)cyclopropyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)thiourea

InChi Key: JWGVUDPAMQEIJU-INIZCTEOSA-N

InChi Code: InChI=1S/C24H31N5O4S2/c1-16-15-33-13-11-29(16)21-14-20(24(8-9-24)35(31,32)19-6-7-19)27-22(28-21)17-2-4-18(5-3-17)26-23(34)25-10-12-30/h2-5,14,16,19,30H,6-13,15H2,1H3,(H2,25,26,34)/t16-/m0/s1

SMILES Code: S=C(NCCO)NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=CC(C4(S(=O)(C5CC5)=O)CC4)=N2)C=C1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 517.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Kurt G. Pike *, Jeff Morris , Linette Ruston , Sarah L. Pass , Ryan Greenwood , Emma J. Williams , Julie Demeritt , Janet D. Culshaw , Kristy Gill , Martin Pass , M. Raymond V. Finlay , Catherine J. Good , Craig A. Roberts , Gordon S. Currie , Kevin Blades , Jonathan M. Eden , and Stuart E. Pearson. Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2. J. Med. Chem., 2015, 58 (5), pp 2326–2349

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AZD3147

1mg / USD 225


Additional Information