WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406639
CAS#: 1619994-68-1
Description: GSK2801 is a A Selective Chemical Probe for BAZ2B/A bromodomains. BAZ2A/B belong to a family of ubiquitously expressed bromodomain containing proteins. Proteins of the BAZ family are characterized by a carboxy-terminal bromodomain adjacent to a PHD finger and a WACZ motif. In addition four other conserved motifs are typically found in the N-terminus of BAZ family members, namely the LH motif (a leucine-rich helical domain), the ZB2 motif and the BAZ 1 and BAZ 2 motifs. Little is known about the biological function of BAZ2B but it has been suggested to regulate nucleosome mobilization by the ATP-dependent chromatin remodeling factor ISWI.
MedKoo Cat#: 406639
Name: GSK2801
CAS#: 1619994-68-1
Chemical Formula: C20H21NO4S
Exact Mass: 371.11913
Molecular Weight: 371.45004
Elemental Analysis: C, 64.67; H, 5.70; N, 3.77; O, 17.23; S, 8.63
GSK2801, purity > 98%, is in stock. The same day shipping out after order is received.
Synonym: GSK2801; GSK-2801; GSK 2801.
IUPAC/Chemical Name: 1-(1-(2-(methylsulfonyl)phenyl)-7-propoxyindolizin-3-yl)ethanone
InChi Key: KHWCPNJRJCNVRI-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
SMILES Code: CC(C1=CC(C2=CC=CC=C2S(=O)(C)=O)=C3C=C(OCCC)C=CN13)=O
The following data is based on the product molecular weight 371.45004 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Chen P, Chaikuad A, Bamborough P, Bantscheff M, Bountra C, Chung CW, Fedorov
O, Grandi P, Jung D, Lesniak R, Lindon M, Müller S, Philpott M, Prinjha R, Rogers
C, Selenski C, Tallant C, Werner T, Willson TM, Knapp S, Drewry DH. Discovery and
Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains
BAZ2A and BAZ2B. J Med Chem. 2015 Apr 6. [Epub ahead of print] PubMed PMID:
25799074.
