WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465432

CAS#: unknown

Description: OAN00639 is a novel Potent PD-L1 Inhibitor (IC50 1.8 nM), binding to human PD-L1 (hPD-L1) with a KD value of 3.34 nM, without showing any binding to hPD-1, blocking PD-1/PD-L1 interaction with an EC50 value of 375 nM.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 465432
Name: OAN00639
CAS#: unknown
Chemical Formula: C30H25BrClN3O6
Exact Mass: 637.06
Molecular Weight: 638.899
Elemental Analysis: C, 56.40; H, 3.94; Br, 12.51; Cl, 5.55; N, 6.58; O, 15.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: OAN00639; OAN 00639; OAN-00639; PD-L1 Inhibitor L7;

IUPAC/Chemical Name: (2-(benzo[c][1,2,5]oxadiazol-5-ylmethoxy)-4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-chlorobenzyl)-D-serine


InChi Code: InChI=1S/C30H25BrClN3O6/c31-29-20(7-4-8-22(29)19-5-2-1-3-6-19)17-40-28-13-27(21(12-23(28)32)14-33-26(15-36)30(37)38)39-16-18-9-10-24-25(11-18)35-41-34-24/h1-13,26,33,36H,14-17H2,(H,37,38)/t26-/m1/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 638.899000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liu L, Yao Z, Wang S, Xie T, Wu G, Zhang H, Zhang P, Wu Y, Yuan H, Sun H. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021 Jun 24;64(12):8391-8409. doi: 10.1021/acs.jmedchem.1c00392. Epub 2021 Jun 11. PMID: 34115499.