WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465422
CAS#: unknown
Description: K-25a is a non-nucleoside reverse Transcriptase inhibitor (NNRTI).
MedKoo Cat#: 465422
Name: K-25a
CAS#: unknown
Chemical Formula: C29H30N6O3S2
Exact Mass: 574.1821
Molecular Weight: 574.718
Elemental Analysis: C, 60.61; H, 5.26; N, 14.62; O, 8.35; S, 11.16
This product is not in stock, which may be available by custom synthesis.
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Note: Price will be listed if it is available in the future.
Synonym: K-25a; K25a; K 25a;
IUPAC/Chemical Name: (E)-4-((4-((4-(4-(2-cyanovinyl)-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzenesulfonamide
InChi Key: GVCHBMCBPBRORW-ONEGZZNKSA-N
InChi Code: InChI=1S/C29H30N6O3S2/c1-19-16-22(4-3-12-30)17-20(2)26(19)38-28-27-25(11-15-39-27)33-29(34-28)32-23-9-13-35(14-10-23)18-21-5-7-24(8-6-21)40(31,36)37/h3-8,11,15-17,23H,9-10,13-14,18H2,1-2H3,(H2,31,36,37)(H,32,33,34)/b4-3+
SMILES Code: CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C(SC=C3)C3=NC(NC4CCN(CC5=CC=C(S(=O)(N)=O)C=C5)CC4)=N2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 574.718 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Renner N, Mallery DL, Faysal KMR, Peng W, Jacques DA, Böcking T, James LC. A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly. PLoS Pathog. 2021 Feb 1;17(2):e1009164. doi: 10.1371/journal.ppat.1009164. PMID: 33524070; PMCID: PMC7850482.
2: Stansell E, Apkarian R, Haubova S, Diehl WE, Tytler EM, Hunter E. Basic residues in the Mason-Pfizer monkey virus gag matrix domain regulate intracellular trafficking and capsid-membrane interactions. J Virol. 2007 Sep;81(17):8977-88. doi: 10.1128/JVI.00657-07. Epub 2007 Jun 27. PMID: 17596311; PMCID: PMC1951391.
3: Martins A, Shuman S. Mutational analysis of baculovirus phosphatase identifies structural residues important for triphosphatase activity in vitro and in vivo. Biochemistry. 2002 Nov 12;41(45):13403-9. doi: 10.1021/bi0265426. PMID: 12416985.
