UZH2
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MedKoo CAT#: 465418

CAS#: 2756566-45-5

Description: UZH2 is a Potent and Selective METTL3 Inhibitor. UZH2 shows target engagement in cells and is able to reduce the m6A/A level of polyadenylated RNA in MOLM-13 (acute myeloid leukemia) and PC-3 (prostate cancer) cell lines.

Chemical Structure

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UZH2
CAS# 2756566-45-5
Instruction

Theoretical Analysis

MedKoo Cat#: 465418
Name: UZH2
CAS#: 2756566-45-5
Chemical Formula: C27H37F2N7O
Exact Mass: 513.30
Molecular Weight: 513.638
Elemental Analysis: C, 63.14; H, 7.26; F, 7.40; N, 19.09; O, 3.11

Price and Availability

Size Price Availability Quantity
5mg USD 950 2 Weeks
25mg USD 2250 2 Weeks
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Synonym: UZH2; UZH 2; UZH-2;

IUPAC/Chemical Name: 4-(4-((4,4-dimethylpiperidin-1-yl)methyl)-2,5-difluorophenyl)-9-(6-(methylamino)pyrimidin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one

InChi Key: GYWOVBUGFWWSJR-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H37F2N7O/c1-26(2)4-8-34(9-5-26)15-19-12-21(29)22(13-20(19)28)36-16-25(37)33-27(17-36)6-10-35(11-7-27)24-14-23(30-3)31-18-32-24/h12-14,18H,4-11,15-17H2,1-3H3,(H,33,37)(H,30,31,32)

SMILES Code: O=C1NC2(CCN(C3=NC=NC(NC)=C3)CC2)CN(C4=CC(F)=C(CN5CCC(C)(C)CC5)C=C4F)C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 513.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dolbois A, Bedi RK, Bochenkova E, Müller A, Moroz-Omori EV, Huang D, Caflisch A. 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J Med Chem. 2021 Aug 25. doi: 10.1021/acs.jmedchem.1c00773. Epub ahead of print. PMID: 34431664.