ZN-c3

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MedKoo CAT#: 465412

CAS#: 2376146-48-2

Description: ZN-c3 is a highly selective Wee1 inhibitor (ICV50 = 3.8 nM) with balanced potency, ADME, and pharmacokinetic properties. ZN-c3 showed excellent in vivo efficacy and is currently being evaluated in phase 2 clinical trials.


Chemical Structure

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ZN-c3
CAS# 2376146-48-2

Theoretical Analysis

MedKoo Cat#: 465412
Name: ZN-c3
CAS#: 2376146-48-2
Chemical Formula: C29H34N8O2
Exact Mass: 526.2805
Molecular Weight: 526.645
Elemental Analysis: C, 66.14; H, 6.51; N, 21.28; O, 6.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ZN-c3; ZNc3; ZN c3;

IUPAC/Chemical Name: (R)-2-allyl-1-(7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

InChi Key: OXTSYWDBUVRXFF-GDLZYMKVSA-N

InChi Code: InChI=1S/C29H34N8O2/c1-4-14-36-27(38)23-19-30-28(31-21-7-9-22(10-8-21)35-17-15-34(3)16-18-35)33-26(23)37(36)24-11-6-20-12-13-29(39,5-2)25(20)32-24/h4,6-11,19,39H,1,5,12-18H2,2-3H3,(H,30,31,33)/t29-/m1/s1

SMILES Code: O=C1N(CC=C)N(C2=CC=C(CC[C@@]3(CC)O)C3=N2)C4=NC(NC5=CC=C(N6CCN(C)CC6)C=C5)=NC=C41

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 526.645 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Huang PQ, Boren BC, Hegde SG, Liu H, Unni AK, Abraham S, Hopkins CD, Paliwal S, Samatar AA, Li J, Bunker KD. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer. J Med Chem. 2021 Aug 23. doi: 10.1021/acs.jmedchem.1c01121. Epub ahead of print. PMID: 34423975.

2: Wu XN, Zhao HT, Li J, Schlangen M, Schwarz H. Highly regioselective hydride transfer, oxidative dehydrogenation, and hydrogen-atom abstraction in the thermal gas-phase chemistry of [Zn(OH)](+)/C3H8. Phys Chem Chem Phys. 2014 Dec 28;16(48):26617-23. doi: 10.1039/c4cp02139h. PMID: 25230924.