Pararosaniline embonate

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MedKoo CAT#: 414765

CAS#: 7460-07-3 (embonate)

Description: Pararosaniline embonate is an Anti-Schistosomal

Chemical Structure

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Pararosaniline embonate
CAS# 7460-07-3 (embonate)
Instruction

Theoretical Analysis

MedKoo Cat#: 414765
Name: Pararosaniline embonate
CAS#: 7460-07-3 (embonate)
Chemical Formula: C42H33N3O6
Exact Mass: 0.00
Molecular Weight: 675.740
Elemental Analysis: C, 74.65; H, 4.92; N, 6.22; O, 14.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 7460-07-3 (embonate); 7232-51-1 (pamoate)  

Synonym: Pararosaniline embonate

IUPAC/Chemical Name: 2-Naphthalenecarboxylic acid, 4,4'-methylenebis(3-hydroxy-, compd. with 4-((4-aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl)benzenamine

InChi Key: WSMURVZCWHMKQP-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H16O6.C19H17N3/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;20-16-7-1-13(2-8-16)19(14-3-9-17(21)10-4-14)15-5-11-18(22)12-6-15/h1-10,24-25H,11H2,(H,26,27)(H,28,29);1-12,20H,21-22H2

SMILES Code: O=C(C1=C(O)C(CC2=C3C=CC=CC3=CC(C(O)=O)=C2O)=C4C=CC=CC4=C1)O.NC5=CC=C(/C(C6=CC=C(N)C=C6)=C7C=CC(C=C\7)=N)C=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 675.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pesigan TP, Banzon TC, Santos AT, Noseñas J, Zabala RG. Pararosaniline pamoate (CI-403-A) in the treatment of Schistosoma japonicum infection in the Philippines. Bull World Health Organ. 1967;36(2):263-74. PMID: 5299751; PMCID: PMC2476386.

2: DA SILVA JR, PRATA A, ARGENTO CA, BRASILHA DO, FERREIRA LF. O CI-403 (PAMOATO DE PARAROSANILINA) NO TRATAMENTO DA ESQUISTOSSOMOSE MANSONI NO BRASIL [CI-403 (PARAROSANILINE PAMOATE) IN THE TREATMENT OF SCHISTOSOMIASIS MANSONI IN BRAZIL]. Hospital (Rio J). 1964 Jul;66:25-34. Portuguese. PMID: 14181573.

3: Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR. Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. Front Microbiol. 2015 Apr 28;6:368. doi: 10.3389/fmicb.2015.00368. PMID: 26029171; PMCID: PMC4429810.

4: BRUAUX P, GILLET J. [Trial of treatment of human bilharziasis due to Schistosoma mansoni by pararosaniline pamoate]. Ann Soc Belg Med Trop (1920). 1961 Oct 31;41:397-401. French. PMID: 13873805.