9-Me-BC
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MedKoo CAT#: 465405

CAS#: 2521-07-5

Description: 9-Me-BC is an analytical reference standard categorized as a nootropic. 9-Methyl-β-carboline improves spatial learning in rats. This product is intended for research and forensic applications. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).


Chemical Structure

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9-Me-BC
CAS# 2521-07-5

Theoretical Analysis

MedKoo Cat#: 465405
Name: 9-Me-BC
CAS#: 2521-07-5
Chemical Formula: C12H10N2
Exact Mass: 182.0844
Molecular Weight: 182.226
Elemental Analysis: C, 79.10; H, 5.53; N, 15.37

Price and Availability

Size Price Availability Quantity
1.0mg USD 220.0 2 Weeks
5.0mg USD 380.0 2 Weeks
Bulk inquiry

Synonym: 9-Me-BC; 9-MeBC; 9-Me BC; 9Me-BC; 9 Me-BC; 9MeBC; 9 Me BC; 9-Methyl-BC; 9-Methyl-norharman; 9-Methyl-β-carboline;

IUPAC/Chemical Name: 9-methyl-9H-pyrido[3,4-b]indole

InChi Key: MABOIYXDALNSES-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H10N2/c1-14-11-5-3-2-4-9(11)10-6-7-13-8-12(10)14/h2-8H,1H3

SMILES Code: CN1C2=C(C3=C1C=NC=C3)C=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 20.0 109.75
DMSO 20.0 109.75
DMSO:PBS (pH 7.2) (1:3) 0.33 1.81

Preparing Stock Solutions

The following data is based on the product molecular weight 182.226 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Keller S, Polanski WH, Enzensperger C, Reichmann H, Hermann A, Gille G. 9-Methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes. J Neural Transm (Vienna). 2020 Jul;127(7):999-1012. doi: 10.1007/s00702-020-02189-9. Epub 2020 Apr 13. PMID: 32285253.

2: Rasse-Suriani FAO, García-Einschlag FS, Rafti M, Schmidt De León T, David Gara PM, Erra-Balsells R, Cabrerizo FM. Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)- and/or N(9)-methyl-β-carboline Derivatives. Photochem Photobiol. 2018 Jan;94(1):36-51. doi: 10.1111/php.12811. Epub 2017 Sep 20. PMID: 28741707.

3: Vignoni M, Rasse-Suriani FA, Butzbach K, Erra-Balsells R, Epe B, Cabrerizo FM. Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines. Org Biomol Chem. 2013 Aug 28;11(32):5300-9. doi: 10.1039/c3ob40344k. PMID: 23842892.

4: Santos CM. New agents promote neuroprotection in Parkinson's disease models. CNS Neurol Disord Drug Targets. 2012 Jun 1;11(4):410-8. doi: 10.2174/187152712800792820. PMID: 22483311.

5: Gruss M, Appenroth D, Flubacher A, Enzensperger C, Bock J, Fleck C, Gille G, Braun K. 9-Methyl-β-carboline-induced cognitive enhancement is associated with elevated hippocampal dopamine levels and dendritic and synaptic proliferation. J Neurochem. 2012 Jun;121(6):924-31. doi: 10.1111/j.1471-4159.2012.07713.x. PMID: 22380576.

6: Gulyaeva N, Aniol V. Good guys from a shady family. J Neurochem. 2012 Jun;121(6):841-2. doi: 10.1111/j.1471-4159.2012.07708.x. PMID: 22372749.

7: Polanski W, Reichmann H, Gille G. Stimulation, protection and regeneration of dopaminergic neurons by 9-methyl-β-carboline: a new anti-Parkinson drug? Expert Rev Neurother. 2011 Jun;11(6):845-60. doi: 10.1586/ern.11.1. PMID: 21651332.

8: Herraiz T, Guillén H. Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors. Food Chem Toxicol. 2011 Aug;49(8):1773-81. doi: 10.1016/j.fct.2011.04.026. Epub 2011 Apr 29. PMID: 21554916.

9: Polanski W, Enzensperger C, Reichmann H, Gille G. The exceptional properties of 9-methyl-beta-carboline: stimulation, protection and regeneration of dopaminergic neurons coupled with anti-inflammatory effects. J Neurochem. 2010 Jun;113(6):1659-75. doi: 10.1111/j.1471-4159.2010.06725.x. Epub 2010 Mar 31. PMID: 20374418.

10: Wernicke C, Hellmann J, Zieba B, Kuter K, Ossowska K, Frenzel M, Dencher NA, Rommelspacher H. 9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson's disease. Pharmacol Rep. 2010 Jan-Feb;62(1):35-53. doi: 10.1016/s1734-1140(10)70241-3. PMID: 20360614.

11: Coronilla AS, Carmona C, Muñoz MA, Balón M. Singlet excited state pyridinic deprotonation of the N9-methylbetacarboline cations in aqueous sodium hydroxide solutions. J Fluoresc. 2010 Jan;20(1):163-70. doi: 10.1007/s10895-009-0534-3. PMID: 19705259.

12: Sánchez Coronilla A, Carmona C, Muñoz MA, Balón M. Ground and singlet excited state pyridinic protonation of N9-methylbetacarboline in water-N,N-dimethylformamide mixtures. J Fluoresc. 2009 Nov;19(6):1025-35. doi: 10.1007/s10895-009-0502-y. Epub 2009 Jun 18. PMID: 19536642.

13: Hamann J, Wernicke C, Lehmann J, Reichmann H, Rommelspacher H, Gille G. 9-Methyl-beta-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic culture. Neurochem Int. 2008 Mar- Apr;52(4-5):688-700. doi: 10.1016/j.neuint.2007.08.018. Epub 2007 Sep 4. PMID: 17913302.

9-Me-BC

1.0mg / USD 220.0