WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406623
Description: SMK-17 is a potent MEK1/2 inhibitor with high aqueous solubility. SMK-17 inhibited MEK1 kinase activity in a non-ATP-competitive manner and it was highly selective to MEK1 and 2. SMK-17 inhibited the growth of tumor cell lines in vitro. Moreover, unlike previously reported MEK inhibitors, PD184352 or U0126, SMK-17 did not inhibit the phosphorylation of ERK5. In vivo, SMK-17 exhibited potent antitumor activity in animal models on oral administration. SMK-17 selectively blocked the MAPK pathway signaling without affecting other signal pathways, which resulted in significant antitumor efficacy without notable side effects.
MedKoo Cat#: 406623
Chemical Formula: C20H24ClF2IN4O2S
Exact Mass: 584.03212
Molecular Weight: 584.85
Elemental Analysis: C, 41.07; H, 4.14; Cl, 6.06; F, 6.50; I, 21.70; N, 9.58; O, 5.47; S, 5.48
Synonym: SMK17; SMK 17; SMK17.
IUPAC/Chemical Name: N-(2-((2-chloro-4-iodophenyl)amino)-3,4-difluorophenyl)-4-(isopropylamino)piperidine-1-sulfonamide
InChi Key: WEULUYVOTSCFRJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H24ClF2IN4O2S/c1-12(2)25-14-7-9-28(10-8-14)31(29,30)27-18-6-4-16(22)19(23)20(18)26-17-5-3-13(24)11-15(17)21/h3-6,11-12,14,25-27H,7-10H2,1-2H3
SMILES Code: O=S(N1CCC(NC(C)C)CC1)(NC2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3Cl)=O
1. Kiga, M. Method for predicting responsiveness to MAPK signaling pathway-inhibiting compound by detecting mutation of ÃŽÂ²-catenin, reagent for detecting the mutation, and treatment of cancer with MAPK signaling pathway inhibitor. WO2014133071A1.