SMK-17

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406623

CAS#: 765958-29-0

Description: SMK-17 is a potent MEK1/2 inhibitor with high aqueous solubility. SMK-17 inhibited MEK1 kinase activity in a non-ATP-competitive manner and it was highly selective to MEK1 and 2. SMK-17 inhibited the growth of tumor cell lines in vitro. Moreover, unlike previously reported MEK inhibitors, PD184352 or U0126, SMK-17 did not inhibit the phosphorylation of ERK5. In vivo, SMK-17 exhibited potent antitumor activity in animal models on oral administration. SMK-17 selectively blocked the MAPK pathway signaling without affecting other signal pathways, which resulted in significant antitumor efficacy without notable side effects.

Chemical Structure

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SMK-17
CAS# 765958-29-0
Instruction

Theoretical Analysis

MedKoo Cat#: 406623
Name: SMK-17
CAS#: 765958-29-0
Chemical Formula: C20H24ClF2IN4O2S
Exact Mass: 584.03
Molecular Weight: 584.850
Elemental Analysis: C, 41.07; H, 4.14; Cl, 6.06; F, 6.50; I, 21.70; N, 9.58; O, 5.47; S, 5.48

Price and Availability

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10mg USD -2
25mg USD -2
50mg USD -2
100mg USD -2
200mg USD -2
500mg USD -2
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Synonym: SMK17; SMK 17; SMK17.

IUPAC/Chemical Name: N-(2-((2-chloro-4-iodophenyl)amino)-3,4-difluorophenyl)-4-(isopropylamino)piperidine-1-sulfonamide

InChi Key: WEULUYVOTSCFRJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H24ClF2IN4O2S/c1-12(2)25-14-7-9-28(10-8-14)31(29,30)27-18-6-4-16(22)19(23)20(18)26-17-5-3-13(24)11-15(17)21/h3-6,11-12,14,25-27H,7-10H2,1-2H3

SMILES Code: O=S(N1CCC(NC(C)C)CC1)(NC2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3Cl)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:         

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 584.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kiga, M. Method for predicting responsiveness to MAPK signaling pathway-inhibiting compound by detecting mutation of β-catenin, reagent for detecting the mutation, and treatment of cancer with MAPK signaling pathway inhibitor. WO2014133071A1.