MedKoo Biosciences

Proguanil free base
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414746

CAS#: 500-92-5 (free base)

Description: Proguanil free base is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.

Chemical Structure

Proguanil free base

CAS# 500-92-5 (free base)

Instruction

Theoretical Analysis

MedKoo Cat#: 414746
Name: Proguanil free base
CAS#: 500-92-5 (free base)
Chemical Formula: C11H16ClN5
Exact Mass: 253.11
Molecular Weight: 253.730
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 52.07; H, 6.36; Cl, 13.97; N, 27.60

Price and Availability

Size	Price	Availability
25mg	USD 350	2 Weeks
50mg	USD 650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 500-92-5 (free base) 637-32-1 (HCl)

Synonym: Proguanil free base; BRN2811599; BRN-2811599; BRN 2811599; Chloroguanide

IUPAC/Chemical Name: Biguanide, 1-(p-chlorophenyl)-5-isopropyl-

InChi Key: SSOLNOMRVKKSON-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)

SMILES Code: N=C(NC(NC(C)C)=N)NC1=CC=C(Cl)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 253.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

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Reconstitution Calculator

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1: Meltzer E, Schwartz E. Atovaquone-proguanil chemoprophylaxis in the era of Tafenoquine. J Travel Med. 2019 Jun 1;26(4):tay133. doi: 10.1093/jtm/tay133. PMID: 30535377.

2: Behrens R, Edwards P. Atovaquone-proguanil exposure in pregnancy should not be condemned from current evidence. Travel Med Infect Dis. 2020 Mar- Apr;34:101559. doi: 10.1016/j.tmaid.2020.101559. Epub 2020 Jan 18. PMID: 31962169.

3: Fleming AF. Proguanil. Lancet. 1989 Feb 25;1(8635):439. doi: 10.1016/s0140-6736(89)90034-2. PMID: 2563814.

4: Osei-Akoto A, Orton L, Owusu-Ofori SP. Atovaquone-proguanil for treating uncomplicated malaria. Cochrane Database Syst Rev. 2005 Oct 19;2005(4):CD004529. doi: 10.1002/14651858.CD004529.pub2. Update in: Cochrane Database Syst Rev. 2021 Jan 15;1:CD004529. PMID: 16235366; PMCID: PMC6532621.

5: Plöger GF, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Parr A, Polli JE, Shah VP, Tajiri T, Dressman JB. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride. J Pharm Sci. 2018 Jul;107(7):1761-1772. doi: 10.1016/j.xphs.2018.03.009. Epub 2018 Mar 20. PMID: 29571740.

6: Marra F, Salzman JR, Ensom MH. Atovaquone-proguanil for prophylaxis and treatment of malaria. Ann Pharmacother. 2003 Sep;37(9):1266-75. doi: 10.1345/aph.1C473. PMID: 12921511.

7: McKeage K, Scott L. Atovaquone/proguanil: a review of its use for the prophylaxis of Plasmodium falciparum malaria. Drugs. 2003;63(6):597-623. doi: 10.2165/00003495-200363060-00006. PMID: 12656656.

8: Patel SN, Kain KC. Atovaquone/proguanil for the prophylaxis and treatment of malaria. Expert Rev Anti Infect Ther. 2005 Dec;3(6):849-61. doi: 10.1586/14787210.3.6.849. PMID: 16307498.

9: Sehdev PS. Atovaquone/proguanil for plasmodium falciparum malaria. Pediatr Infect Dis J. 2002 Aug;21(8):787-9. doi: 10.1097/00006454-200208000-00017. PMID: 12192170.

10: Kremsner PG, Looareesuwan S, Chulay JD. Atovaquone and proguanil hydrochloride for treatment of malaria. J Travel Med. 1999 May;6 Suppl 1:S18-20. PMID: 23573548.

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Proguanil free base featured