WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406620
Description: CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM. CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM).
MedKoo Cat#: 406620
Chemical Formula: C22H30N4O6
Exact Mass: 446.21653
Molecular Weight: 446.5
Elemental Analysis: C, 59.18; H, 6.77; N, 12.55; O, 21.50
CAY10603 purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: CAY10603; CAY-10603; CAY 10603.
IUPAC/Chemical Name: tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate
InChi Key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
SMILES Code: O=C(OC(C)(C)C)NC1=CC=C(C2=CC(C(NCCCCCCC(NO)=O)=O)=NO2)C=C1
The following data is based on the product molecular weight 446.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Kozikowski AP, Tapadar S, Luchini DN, Kim KH, Billadeau DD. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem. 2008 Aug 14;51(15):4370-3. doi: 10.1021/jm8002894. Epub 2008 Jul 22. PubMed PMID: 18642892; PubMed Central PMCID: PMC3913184.