Oxycardin

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MedKoo CAT#: 414698

CAS#: 67970-62-1

Description: Oxycardin is in a group of drugs called nitrates. Oxycardin dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump. Oxycardin is used to prevent angina attacks (chest pain). Oxycardin will not treat an angina attack that has already begun.

Chemical Structure

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Oxycardin
CAS# 67970-62-1
Instruction

Theoretical Analysis

MedKoo Cat#: 414698
Name: Oxycardin
CAS#: 67970-62-1
Chemical Formula: C20H31Cl2N3O10
Exact Mass: 543.14
Molecular Weight: 544.380
Elemental Analysis: C, 44.13; H, 5.74; Cl, 13.02; N, 7.72; O, 29.39

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Oxycardin

IUPAC/Chemical Name: (3R,3aS,6S,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate compound with 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol (1:1) hydrochloride

InChi Key: UJQNCDJPZGORII-SADXPQEKSA-N

InChi Code: InChI=1S/C14H22ClNO2.C6H8N2O8.ClH/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4;9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6;/h5-7,11,16-17H,8-9H2,1-4H3;3-6H,1-2H2;1H/t;3-,4+,5-,6-;/m.1./s1

SMILES Code: Cc1cc(OCC(CNC(C)(C)C)O)c(Cl)cc1.[O-][N+](O[C@H]2CO[C@@H]3[C@H](O[N+]([O-])=O)CO[C@H]23)=O.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 544.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Trif V, Oancea I. Wirkung bon Oxycardin auf den Augeninnendruck [Effect of oxycardin on the intraocular pressure]. Med Welt. 1978 Jun 30;29(26):1100-4. German. PMID: 27693.

2: Philipp R, Kutscha W. Zur Behandlung der Koronarinsuffizienz. Vergleichsstudie über die Wirkung eines Nitropräparates (Isosorbiddinitrat), eines Betasympathikolytikums (Bupranolol) und eines Kombinationspräparates (Oxycardin) [Treatment of coronary insufficiency. Comparative study on the effect of a nitro compound (isosorbidedinitrate), a beta sympatholytic (bupranolol) and a drug combination (oxycardin)]. Med Welt. 1980 May 23;31(21):817-20. German. PMID: 7392937.

3: Tuluweit K, Strauss G. Langzeitbehandlung der koronaren Herzkrankheit mit begleitender Hypertonie. Oxycardin retard beim Koronarhypertoniker [Long-term treatment of coronary heart disease with concomitant hypertension. Oxycardin retard in the coronary hypertensive patient]. ZFA (Stuttgart). 1983 Mar 10;59(7):388-94. German. PMID: 6845862.

4: Hoffmann J. Die Behandlung der koronaren Herzkrankheit. Oxycardin retard bei gleichzeitig bestehender arterieller Hypertonie [Treatment of coronary heart disease. Oxycardin retard in simultaneously existing arterial hypertension]. Fortschr Med. 1983 Apr 28;101(16):764-7. German. PMID: 6852752.

5: Oancea I. Wirkung von Oxycardin im Akutversuch auf den Augeninnendruck von Patienten mit chronischem Glaucoma simplex [The immediate effect of beta-isoket on the internal ocular pressure in patients with chronic simple glaucoma (author's transl)]. Klin Monbl Augenheilkd. 1975 Oct;167(4):618-22. German. PMID: 1574.