CAM741

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465358

CAS#: 177586-74-2

Description: CAM741 is a novel selective inhibitor of vascular cell adhesion molecule 1 (VCAM1) synthesis in endothelial cells, blocking the process of cotranslational translocation, which is dependent on the signal peptide of VCAM1.

Chemical Structure

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CAM741
CAS# 177586-74-2
Instruction

Theoretical Analysis

MedKoo Cat#: 465358
Name: CAM741
CAS#: 177586-74-2
Chemical Formula: C56H91N7O11
Exact Mass: 1,037.68
Molecular Weight: 1,038.382
Elemental Analysis: C, 64.78; H, 8.83; N, 9.44; O, 16.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CAM741; CAM 741; CAM-741;

IUPAC/Chemical Name: propyl 3-((2R,5S,8S,11S,14S,17S,20S)-8,11-diisobutyl-14-((1-methoxy-1H-indol-3-yl)methyl)-7,13,19,20-tetramethyl-5,17-bis((R)-2-methylhexyl)-3,6,9,12,15,18,21-heptaoxo-1-oxa-4,7,10,13,16,19-hexaazacyclohenicosan-2-yl)propanoate

InChi Key: VDFZHYIUDDBVPN-IVUNSTSTSA-N

InChi Code: InChI=1S/C56H91N7O11/c1-15-18-22-37(8)31-43-53(68)60(11)39(10)56(71)74-48(26-27-49(64)73-28-17-3)52(67)59-44(32-38(9)23-19-16-2)55(70)61(12)46(30-36(6)7)50(65)57-42(29-35(4)5)54(69)62(13)47(51(66)58-43)33-40-34-63(72-14)45-25-21-20-24-41(40)45/h20-21,24-25,34-39,42-44,46-48H,15-19,22-23,26-33H2,1-14H3,(H,57,65)(H,58,66)(H,59,67)/t37-,38-,39+,42+,43+,44+,46+,47+,48-/m1/s1

SMILES Code: O=C(OCCC)CC[C@H](C(N[C@@H](C[C@H](C)CCCC)C(N(C)[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N(C)[C@@H](CC1=CN(OC)C2=C1C=CC=C2)C(N[C@@H](C[C@H](C)CCCC)C(N(C)[C@H]3C)=O)=O)=O)=O)=O)=O)OC3=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,038.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Schorr S, Nguyen D, Haßdenteufel S, Nagaraj N, Cavalié A, Greiner M, Weissgerber P, Loi M, Paton AW, Paton JC, Molinari M, Förster F, Dudek J, Lang S, Helms V, Zimmermann R. Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import. FEBS J. 2020 Nov;287(21):4612-4640. doi: 10.1111/febs.15274. Epub 2020 Mar 20. PMID: 32133789.

2: Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S, Zimmermann R. Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier. Cell Rep. 2018 May 1;23(5):1373-1386. doi: 10.1016/j.celrep.2018.03.122. PMID: 29719251; PMCID: PMC5946456.

3: Westendorf C, Schmidt A, Coin I, Furkert J, Ridelis I, Zampatis D, Rutz C, Wiesner B, Rosenthal W, Beyermann M, Schülein R. Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin. J Biol Chem. 2011 Oct 14;286(41):35588-35600. doi: 10.1074/jbc.M111.239244. Epub 2011 Jul 30. PMID: 21808059; PMCID: PMC3195616.

4: Harant H, Wolff B, Schreiner EP, Oberhauser B, Hofer L, Lettner N, Maier S, de Vries JE, Lindley IJ. Inhibition of vascular endothelial growth factor cotranslational translocation by the cyclopeptolide CAM741. Mol Pharmacol. 2007 Jun;71(6):1657-65. doi: 10.1124/mol.107.034249. Epub 2007 Mar 16. PMID: 17369307.

5: Harant H, Lettner N, Hofer L, Oberhauser B, de Vries JE, Lindley IJ. The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon. J Biol Chem. 2006 Oct 13;281(41):30492-502. doi: 10.1074/jbc.M607243200. Epub 2006 Aug 16. PMID: 16914554.

6: Besemer J, Harant H, Wang S, Oberhauser B, Marquardt K, Foster CA, Schreiner EP, de Vries JE, Dascher-Nadel C, Lindley IJ. Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1. Nature. 2005 Jul 14;436(7048):290-3. doi: 10.1038/nature03670. PMID: 16015337.