ZY12201

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465355

CAS#: unknown

Description: ZY12201 is a novel potent and orally bioavailable TGR5 agonist.

Chemical Structure

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ZY12201
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465355
Name: ZY12201
CAS#: unknown
Chemical Formula: C31H31FN4O3S
Exact Mass: 558.21
Molecular Weight: 558.672
Elemental Analysis: C, 66.65; H, 5.59; F, 3.40; N, 10.03; O, 8.59; S, 5.74

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ZY12201; ZY 12201; ZY-12201;

IUPAC/Chemical Name: 2-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

InChi Key: ZRQBEFYILDBORB-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H31FN4O3S/c1-31(2,22-5-14-27(37-3)28(19-22)38-4)29-20-34-30(36(29)25-8-6-23(32)7-9-25)40-18-17-39-26-12-10-24(11-13-26)35-16-15-33-21-35/h5-16,19-21H,17-18H2,1-4H3

SMILES Code: FC1=CC=C(N2C(C(C)(C3=CC=C(OC)C(OC)=C3)C)=CN=C2SCCOC4=CC=C(N5C=CN=C5)C=C4)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 558.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sojitra C, Dholakia C, Sudhakar P, Singh KK, Agarwal S. Identification of degradation impurity of TGR5 receptor agonist-ZY12201 by LC-MS technique during force degradation study. SN Appl Sci. 2021;3(6):660. doi: 10.1007/s42452-021-04660-y. Epub 2021 May 25. PMID: 34056545; PMCID: PMC8144688.