Oxyphenonium Free Base

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MedKoo CAT#: 414682

CAS#: 14214-84-7 (free base)

Description: Oxyphenonium Free Base is a quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.

Chemical Structure

Oxyphenonium Free Base
CAS# 14214-84-7 (free base)

Theoretical Analysis

MedKoo Cat#: 414682
Name: Oxyphenonium Free Base
CAS#: 14214-84-7 (free base)
Chemical Formula: C21H34NO3+
Exact Mass: 348.2533
Molecular Weight: 348.51
Elemental Analysis: C, 72.37; H, 9.83; N, 4.02; O, 13.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 50-10-2 (Br); 14214-84-7 (free base)  

Synonym: Oxyphenonium Free Base

IUPAC/Chemical Name: Ethanaminium, 2-((cyclohexylhydroxyphenylacetyl)oxy)-N,N-diethyl-N-methyl-


InChi Code: InChI=1S/C21H34NO3/c1-4-22(3,5-2)16-17-25-20(23)21(24,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6,8-9,12-13,19,24H,4-5,7,10-11,14-17H2,1-3H3/q+1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 348.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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7: Feitsma KG, Postma DS, Koëter GH, Nossent GD, Brenth BF, de Zeeuw RA. Comparative study of the bronchodilating effects of (-)- and (+)-oxyphenonium bromide. Br J Clin Pharmacol. 1988 Jun;25(6):683-7. doi: 10.1111/j.1365-2125.1988.tb05253.x. PMID: 3144299; PMCID: PMC1386444.

8: Scholtmeijer RJ, van Mastrigt R. The effect of oxyphenonium bromide and oxybutynin hydrochloride on detrusor contractility and reflux in children with vesicoureteral reflux and detrusor instability. J Urol. 1991 Aug;146(2 ( Pt 2)):660-2. doi: 10.1016/s0022-5347(17)37887-4. PMID: 1907331.

9: Pokora J, Kleinrok Z, Chodkowska A, Skrzydło-Radomańska B. Effects of pentagastrin and oxyphenonium on the levels of serotonin and 5-hydroxyindoleacetic acid in different parts of the digestive tract, blood and brain of rats. Acta Physiol Pol. 1984 Jul-Aug;35(4):317-23. PMID: 6085901.

10: LEVINE RM, CLARK BB. The physiological disposition of oxyphenonium bromide (antrenyl) and related compounds. J Pharmacol Exp Ther. 1957 Sep;121(1):63-70. PMID: 13481828.