Seletalisib

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206179

CAS#: 1362850-20-1

Description: Seletalisib, also known as UCB-5857, is a potent and selective PI3 kinase inhibitor, which may be useful for the treatment of immune-inflammatory diseases.


Chemical Structure

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Seletalisib
CAS# 1362850-20-1

Theoretical Analysis

MedKoo Cat#: 206179
Name: Seletalisib
CAS#: 1362850-20-1
Chemical Formula: C23H14ClF3N6O
Exact Mass: 482.08697
Molecular Weight: 482.85
Elemental Analysis: C, 57.21; H, 2.92; Cl, 7.34; F, 11.80; N, 17.41; O, 3.31

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Synonym: UCB-5857; UCB 5857; UCB5857; Seletalisib.

IUPAC/Chemical Name: (R)-3-(8-chloro-3-(2,2,2-trifluoro-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl)quinolin-2-yl)pyridine 1-oxide

InChi Key: LNLJHGXOFYUARS-OAQYLSRUSA-N

InChi Code: InChI=1S/C23H14ClF3N6O/c24-16-6-1-4-13-10-15(18(31-19(13)16)14-5-3-9-33(34)11-14)21(23(25,26)27)32-22-20-17(29-12-30-22)7-2-8-28-20/h1-12,21H,(H,29,30,32)/t21-/m1/s1

SMILES Code: FC(F)(F)[C@@H](C1=CC2=CC=CC(Cl)=C2N=C1C3=CC=C[N+]([O-])=C3)NC4=C5C(C=CC=N5)=NC=N4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 482.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information