WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465311
CAS#: 529-55-5
Description: Prunin is a polyketide synthase-derived flavonoid glycoside that has been found in G. glabra and has diverse biological activities. It inhibits neuraminidase (NA) activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 3 and 4.53 µM, respectively). Prunin (2 µM) scavenges DPPH radicals in a cell-free assay. It inhibits the activity of protein tyrosine phosphatase 1B (PTP1B; IC50 = 5.5 µM for the human enzyme) and increases insulin-induced glucose uptake in insulin-resistant HepG2 hepatocellular carcinoma cells in a concentration-dependent manner. Prunin inhibits the proliferation of, and induces apoptosis in, HL-60 leukemia cells.
MedKoo Cat#: 465311
Name: Prunin
CAS#: 529-55-5
Chemical Formula: C21H22O10
Exact Mass: 434.1213
Molecular Weight: 434.397
Elemental Analysis: C, 58.06; H, 5.11; O, 36.83
Synonym: Prunin; Naringenin 7-O-β-D-glucopyranoside; Naringenin 7-O-glucoside; NSC 135064; NSC-135064; NSC135064;
IUPAC/Chemical Name: (S)-5-hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one
InChi Key: DLIKSSGEMUFQOK-SFTVRKLSSA-N
InChi Code: InChI=1S/C21H22O10/c22-8-16-18(26)19(27)20(28)21(31-16)29-11-5-12(24)17-13(25)7-14(30-15(17)6-11)9-1-3-10(23)4-2-9/h1-6,14,16,18-24,26-28H,7-8H2/t14-,16+,18+,19-,20+,21+/m0/s1
SMILES Code: OC1=C2C(O[C@H](C3=CC=C(C=C3)O)CC2=O)=CC(O[C@@H]4O[C@H](CO)[C@@H](O)[C@@H]([C@H]4O)O)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.0 | 46.04 | |
| DMF | 30.0 | 69.06 | |
| DMF:PBS (pH 7.2) (1:2) | 0.3 | 0.69 |
The following data is based on the product molecular weight 434.397 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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