WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 414664
CAS#: 35578-20-2
Description: Oxarbazole is an antagonist of slow-reacting substance of anaphylaxis.
MedKoo Cat#: 414664
Name: Oxarbazole
CAS#: 35578-20-2
Chemical Formula: C21H19NO4
Exact Mass: 349.1314
Molecular Weight: 349.39
Elemental Analysis: C, 72.19; H, 5.48; N, 4.01; O, 18.32
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Synonym: Oxarbazole; Win34284; Win-34284; Win 34284
IUPAC/Chemical Name: 1H-Carbazole-3-carboxylic acid, 9-benzoyl-2,3,4,9-tetrahydro-6-methoxy-
InChi Key: ZNHCPKKNDKCPDG-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19NO4/c1-26-15-8-10-19-17(12-15)16-11-14(21(24)25)7-9-18(16)22(19)20(23)13-5-3-2-4-6-13/h2-6,8,10,12,14H,7,9,11H2,1H3,(H,24,25)
SMILES Code: O=C(C1CCC(N(C(C2=CC=CC=C2)=O)C3=C4C=C(OC)C=C3)=C4C1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 349.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Benziger D, Dorrbecker S, Goehl T, Edelson J. Absorption and disposition of oxarbazole in man and laboratory animals. Drug Metab Dispos. 1978 Jan- Feb;6(1):8-15. PMID: 23278.
2: Edelson J, Benziger DP. Disposition of a series of tetrahydrocarbazoles. Drug Metab Rev. 1980;11(2):263-89. doi: 10.3109/03602538008994027. PMID: 7011760.
3: Mielens ZE. Evaluation of the antiasthmatic potential of oxarbazole in guinea pigs. Pharmacology. 1978;17(6):323-9. doi: 10.1159/000136873. PMID: 733892.
4: Furukawa CT. Other pharmacologic agents that may affect bronchial hyperreactivity. J Allergy Clin Immunol. 1984 May;73(5 Pt 2):693-8. doi: 10.1016/0091-6749(84)90308-7. PMID: 6143771.
5: Mielens ZE, Ferguson EW, Ferrari RA. Pharmacologic characterization of immune complex induced bronchoconstriction in guinea pigs. Agents Actions. 1981 Dec;11(6-7):673-8. doi: 10.1007/BF01978788. PMID: 6462038.
6: Mielens ZE. The effects of antiasthmatic drugs against immune complex-induced bronchoconstriction in anesthetized dogs. Pharmacology. 1979;18(6):311-8. doi: 10.1159/000137271. PMID: 115021.
