Oxophenarsine Free Base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414663

CAS#: 306-12-7 (free base)

Description: Oxophenarsine Free Base is an obsolete toxic arsenical for treatment of syphilis; useful against some neoplasms.

Chemical Structure

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Oxophenarsine Free Base
CAS# 306-12-7 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 414663
Name: Oxophenarsine Free Base
CAS#: 306-12-7 (free base)
Chemical Formula: C6H6AsNO2
Exact Mass: 198.96
Molecular Weight: 199.040
Elemental Analysis: C, 36.21; H, 3.04; As, 37.64; N, 7.04; O, 16.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 306-12-7 (free base); 538-03-4 (HCl)  

Synonym: Oxophenarsine Free Base; NSC135784; NSC-135784; NSC 135784

IUPAC/Chemical Name: 2-amino-4-(oxoarsanyl)phenol

InChi Key: KVGGQNNGLOIZSK-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H6AsNO2/c8-5-3-4(7-10)1-2-6(5)9/h1-3,9H,8H2

SMILES Code: Nc1c(O)ccc([As]=O)c1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 199.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gupta P, Balachandran R, Thampatty P, Rinaldo C, Ho M. Oxophenarsine, an antisyphilis drug inhibits HIV-1-specific protein synthesis in acutely and persistently infected lymphocytes. AIDS Res Hum Retroviruses. 1990 Dec;6(12):1417-23. doi: 10.1089/aid.1990.6.1417. PMID: 2078419.

2: LEONARD CS. Influence of oxophenarsine on hypoglycemic action of insulin. Proc Soc Exp Biol Med. 1948 Jan;67(1):89-92. doi: 10.3181/00379727-67-16214. PMID: 18902303.

3: KOLMER JA. Penicillin in the treatment of experimental syphilis of rabbits. VII. Penicillin "S-R" and procaine penicillin G in peanut oil with aluminum monostearate, alone and in combination with oxophenarsine hydrochloride (mapharsen) or bismuth subsalicylate. AMA Arch Derm Syphilol. 1951 Aug;64(2):169-76. doi: 10.1001/archderm.1951.01570080053008. PMID: 14856407.

4: KNOCK FE. NEWER ANTICANCER AGENTS. Med Clin North Am. 1964 Mar;48:501-27. doi: 10.1016/s0025-7125(16)33478-2. PMID: 14151253.

5: HYMAN AB. Oxophenarsine hydrochloride in treatment of lupus erythematosus. Arch Derm Syphilol. 1946 Jan;53:26-30. doi: 10.1001/archderm.1946.01510300029006. PMID: 21013470.

6: "Found: A One Day Cure for Syphilis". JAMA. 2017 Sep 5;318(9):871. doi: 10.1001/jama.2017.10226. PMID: 28873151.

7: ALEXANDER LJ, SCHOCH AG. Prevention of syphilis; penicillin calcium in oil and white wax, U.S. P., bismuth ethylcamphorate and oxophenarsine hydrochloride in treatment, during incubation stage, of persons exposed to syphilis. Arch Derm Syphilol. 1949 Jan;59(1):1-10. doi: 10.1001/archderm.1949.01520260005001. PMID: 18110552.

8: GREEN RA, KILLICK F. An oxygen-cylinder carrier. Lancet. 1954 Dec 18;267(6851):1266. doi: 10.1016/s0140-6736(54)92055-3. PMID: 13213179.

9: Ott KJ, Stauber LA. Eperythrozoon coccoides: influence on course of infection of Plasmodium chabaudi in mouse. Science. 1967 Mar 24;155(3769):1546-8. doi: 10.1126/science.155.3769.1546. PMID: 6020473.

10: CANTRELL W. The effect of oxophenarsine on the phosphate metabolism of Trypanosoma equiperdum in the rat. J Infect Dis. 1954 Jul-Aug;95(1):92-7. doi: 10.1093/infdis/95.1.92. PMID: 13184170.