Oxacillin Free Base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414659

CAS#: 66-79-5 (free base)

Description: Oxacillin Free Base is an antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.


Chemical Structure

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Oxacillin Free Base
CAS# 66-79-5 (free base)

Theoretical Analysis

MedKoo Cat#: 414659
Name: Oxacillin Free Base
CAS#: 66-79-5 (free base)
Chemical Formula: C19H19N3O5S
Exact Mass: 401.1045
Molecular Weight: 401.44
Elemental Analysis: C, 56.85; H, 4.77; N, 10.47; O, 19.93; S, 7.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 1173-88-2 (sodium)   66-79-5 (free base)   7240-38-2 (sodium hydrate)    

Synonym: Oxacillin Free Base; MPi-PC; MPI-penicillin; Prostaphlyn

IUPAC/Chemical Name: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(((5-methyl-3-phenyl-4-isoxazolyl)carbonyl)amino)-7-oxo-, (2S-(2alpha,5alpha,6beta))-

InChi Key: UWYHMGVUTGAWSP-JKIFEVAISA-N

InChi Code: InChI=1S/C19H19N3O5S/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26)/t13-,14+,17-/m1/s1

SMILES Code: O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=CC=CC=C4)=O)N1C2=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 401.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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10: Chovanová R, Mikulášová M, Vaverková Š. Modulation of mecA Gene Expression by Essential Oil from Salvia sclarea and Synergism with Oxacillin in Methicillin Resistant Staphylococcus epidermidis Carrying Different Types of Staphylococcal Chromosomal Cassette mec. Int J Microbiol. 2016;2016:6475837. doi: 10.1155/2016/6475837. Epub 2016 Jan 6. PubMed PMID: 26880926; PubMed Central PMCID: PMC4736799.

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12: Serna-Galvis EA, Silva-Agredo J, Giraldo AL, Flórez-Acosta OA, Torres-Palma RA. Comparative study of the effect of pharmaceutical additives on the elimination of antibiotic activity during the treatment of oxacillin in water by the photo-Fenton, TiO2-photocatalysis and electrochemical processes. Sci Total Environ. 2016 Jan 15;541:1431-8. doi: 10.1016/j.scitotenv.2015.10.029. Epub 2015 Nov 11. PubMed PMID: 26479916.

13: Kong LY, Jean A, Wong H, Semret M, Frenette C, Simor AE, Fenn S, Loo VG. Bacteremia caused by a mecA-positive oxacillin-susceptible Staphylococcus aureus strain with inducible resistance. Diagn Microbiol Infect Dis. 2015 Dec;83(4):377-8. doi: 10.1016/j.diagmicrobio.2015.09.001. Epub 2015 Sep 4. PubMed PMID: 26422086.

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19: Tuon FF, Rocha JL, Morales HM, Sakumoto MH, Miksza KF, Pecoit-Filho R. Modulation of inflammatory mediators during treatment of cellulitis with daptomycin or vancomycin/oxacillin. Int J Antimicrob Agents. 2015 Oct;46(4):476-8. doi: 10.1016/j.ijantimicag.2015.05.018. Epub 2015 Jul 2. PubMed PMID: 26187364.

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