WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406604
Description: HJC0197 is a EPAC (erythromycin propionate-N-acetylcysteinate) inhibitor. EPAC inhibitor may prevent pancreatic cancer cell migration and invasion.
MedKoo Cat#: 406604
Chemical Formula: C19H21N3OS
Exact Mass: 339.14053
Molecular Weight: 339.45
Elemental Analysis: C, 67.23; H, 6.24; N, 12.38; O, 4.71; S, 9.45
HJC0197, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: HJC0197; HJC-0197; HJC 0197.
IUPAC/Chemical Name: 4-cyclopentyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
InChi Key: QLLWRTHDHRGHQZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H21N3OS/c1-12-7-8-13(2)15(9-12)11-24-19-21-17(14-5-3-4-6-14)16(10-20)18(23)22-19/h7-9,14H,3-6,11H2,1-2H3,(H,21,22,23)
SMILES Code: N#CC1=C(C2CCCC2)N=C(SCC3=CC(C)=CC=C3C)NC1=O
The following data is based on the product molecular weight 339.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: JuhÃ¡sz T, Matta C, Somogyi C, Katona Ã‰, TakÃ¡cs R, Soha RF, SzabÃ³ IA, CserhÃ¡ti C, Sződy R, KarÃ¡csonyi Z, BakÃ³ E, Gergely P, ZÃ¡kÃ¡ny R. Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures. Cell Signal. 2014 Mar;26(3):468-82. doi: 10.1016/j.cellsig.2013.12.001. Epub 2013 Dec 12. PubMed PMID: 24333667.
2: Rehmann H. Epac-inhibitors: facts and artefacts. Sci Rep. 2013 Oct 23;3:3032. doi: 10.1038/srep03032. PubMed PMID: 24149987; PubMed Central PMCID: PMC3805970.