WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406604
Description: HJC0197 is a EPAC (erythromycin propionate-N-acetylcysteinate) inhibitor. EPAC inhibitor may prevent pancreatic cancer cell migration and invasion.
MedKoo Cat#: 406604
Chemical Formula: C19H21N3OS
Exact Mass: 339.14053
Molecular Weight: 339.45
Elemental Analysis: C, 67.23; H, 6.24; N, 12.38; O, 4.71; S, 9.45
Synonym: HJC0197; HJC-0197; HJC 0197.
IUPAC/Chemical Name: 4-cyclopentyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
InChi Key: QLLWRTHDHRGHQZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H21N3OS/c1-12-7-8-13(2)15(9-12)11-24-19-21-17(14-5-3-4-6-14)16(10-20)18(23)22-19/h7-9,14H,3-6,11H2,1-2H3,(H,21,22,23)
SMILES Code: N#CC1=C(C2CCCC2)N=C(SCC3=CC(C)=CC=C3C)NC1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 339.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: JuhÃ¡sz T, Matta C, Somogyi C, Katona Ã‰, TakÃ¡cs R, Soha RF, SzabÃ³ IA, CserhÃ¡ti C, Sződy R, KarÃ¡csonyi Z, BakÃ³ E, Gergely P, ZÃ¡kÃ¡ny R. Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures. Cell Signal. 2014 Mar;26(3):468-82. doi: 10.1016/j.cellsig.2013.12.001. Epub 2013 Dec 12. PubMed PMID: 24333667.
2: Rehmann H. Epac-inhibitors: facts and artefacts. Sci Rep. 2013 Oct 23;3:3032. doi: 10.1038/srep03032. PubMed PMID: 24149987; PubMed Central PMCID: PMC3805970.