WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406601
Description: JIB-04, also known as NSC 693627, is a Jumonji histone demethylase inhibitor. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer.
MedKoo Cat#: 406601
Chemical Formula: C17H13ClN4
Exact Mass: 308.08287
Molecular Weight: 308.76
Elemental Analysis: C, 66.13; H, 4.24; Cl, 11.48; N, 18.15
JIB-04, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Related CAS #: 199596-05-9 (JIB04) 199596-24-2 (JIB04 Z-isomer)
Synonym: JIB04; JIB-04; JIB 04; NSC 693627; NSC-693627; NSC 693627.
IUPAC/Chemical Name: (E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine
InChi Key: YHHFKWKMXWRVTJ-OQKWZONESA-N
InChi Code: InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+
SMILES Code: ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1
The following data is based on the product molecular weight 308.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Van Rechem C, Black JC, Boukhali M, Aryee MJ, Graslund S, Haas W, Benes CH, Whetstine JR. Lysine Demethylase KDM4A Associates with Translation Machinery and Regulates Protein Synthesis. Cancer Discov. 2015 Jan 6. pii: CD-14-1326. [Epub ahead of print] PubMed PMID: 25564516.
2: Sekar TV, Foygel K, Gelovani JG, Paulmurugan R. Genetically Encoded Molecular Biosensors To Image Histone Methylation in Living Animals. Anal Chem. 2014 Dec 24. [Epub ahead of print] PubMed PMID: 25506787.
3: Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, PeÃ±a-Llopis S, Xu J, Babinski DJ, Frantz DE, Brekken RA, Quinn AM, Simeonov A, Easmon J, Martinez ED. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. doi: 10.1038/ncomms3035. Erratum in: Nat Commun. 2013;4:2639. PubMed PMID: 23792809; PubMed Central PMCID: PMC3724450.