Oxaflumazine Free Base

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MedKoo CAT#: 414644

CAS#: 16498-21-8 (free base)

Description: Oxaflumazine Free Base is a Psychosedative.

Chemical Structure

Oxaflumazine Free Base
CAS# 16498-21-8 (free base)

Theoretical Analysis

MedKoo Cat#: 414644
Name: Oxaflumazine Free Base
CAS#: 16498-21-8 (free base)
Chemical Formula: C26H32F3N3O2S
Exact Mass: 507.2167
Molecular Weight: 507.62
Elemental Analysis: C, 61.52; H, 6.35; F, 11.23; N, 8.28; O, 6.30; S, 6.32

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 16498-21-8 (free base); 7450-97-7 (disuccinate)  

Synonym: Oxaflumazine Free Base; SD270-31; SD-270-31; SD 270-31

IUPAC/Chemical Name: 10-(3-(4-(2-m-Dioxanylethyl)-1-piperazinyl)propyl)-2-(trifluoromethyl) phenothiazine


InChi Code: InChI=1S/C26H32F3N3O2S/c27-26(28,29)20-7-8-24-22(19-20)32(21-5-1-2-6-23(21)35-24)11-3-10-30-13-15-31(16-14-30)12-9-25-33-17-4-18-34-25/h1-2,5-8,19,25H,3-4,9-18H2


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 507.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Boissier JR, Gérardin A, Dumont C. Métabolisme de l'oxaflumazine [Metabolism of oxaflumazine]. Ann Pharm Fr. 1972 Dec;30(12):851-60. French. PMID: 4148298.

2: Lambert PA. L'action neuroleptique de l'oxaflumazine, en particulier dans les psychoses aiguës [Neuroleptic effect of oxaflumazine, especially in acute psychoses]. Therapeutique. 1972 May-Jun;48(5):385-90. French. PMID: 4403943.

3: Sichel JP, Poupier G. Expérimentation du disuccinate acide d'oxaflumazine sur 24 cas d'enfants psychotiques en milieu pédo-psychiatrique [Experimental study of oxaflumazine acid disuccinate in the treatment of 24 cases of psychotic children in a pedopsychiatric environment]. Rev Neuropsychiatr Infant. 1972 Mar- Apr;20(3):367-74. French. PMID: 5055026.

4: Deniker P, Ginestet D, Peron-Magnan P, Colonna L, Loo H. Etude clinique de l'oxaflumazine; sa place parmi les neuroleptiques [Clinical study of oxaflumazine; its place among the neuroleptics]. Therapie. 1971 Jan- Feb;26(1):227-33. French. PMID: 5554766.

5: Villeneuve A, Dogan K, Lachance R, Drolet A. Une étude pilote de l'oxaflumazine, une nouvelle phenothiazine pipérazinée [Pilot study on oxaflumazine, a new piperazinated phenothiazine]. Int J Clin Pharmacol. 1972 Aug;6(3):246-55. French. PMID: 4405378.

6: Boissier JR, Dumont C. Etude pharmacologique d'un nouveau dérivé neuroleptique: l'oxaflumazine [Pharmacological study of a new neuroleptic derivated drug: oxaflumazine]. Therapie. 1971 May-Jun;26(3):481-96. French. PMID: 5113801.