Osemozotan Free Base

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MedKoo CAT#: 414641

CAS#: 137275-81-1 (free base)

Description: Osemozotan Free Base is a 5-HT(1A) receptor agonist.

Chemical Structure

Osemozotan Free Base
CAS# 137275-81-1 (free base)

Theoretical Analysis

MedKoo Cat#: 414641
Name: Osemozotan Free Base
CAS#: 137275-81-1 (free base)
Chemical Formula: C19H21NO5
Exact Mass: 343.14
Molecular Weight: 343.380
Elemental Analysis: C, 66.46; H, 6.16; N, 4.08; O, 23.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 137275-81-1 (free base)   137275-80-0 (HCl)    

Synonym: Osemozotan Free Base

IUPAC/Chemical Name: 3-(1,3-Benzodioxol-5-yloxy)-N-(((2S)-2,3-dihydro-1,4-benzodioxin-2-yl)methyl)propan-1-amine


InChi Code: InChI=1S/C19H21NO5/c1-2-5-18-16(4-1)22-12-15(25-18)11-20-8-3-9-21-14-6-7-17-19(10-14)24-13-23-17/h1-2,4-7,10,15,20H,3,8-9,11-13H2/t15-/m0/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 343.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Matsuda T. Neuropharmacologic studies on the brain serotonin1A receptor using the selective agonist osemozotan. Biol Pharm Bull. 2013;36(12):1871-82. doi: 10.1248/bpb.b13-00645. PMID: 24292048.

2: Tsuchida R, Kubo M, Kuroda M, Shibasaki Y, Shintani N, Abe M, Köves K, Hashimoto H, Baba A. An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice. J Pharmacol Sci. 2009 Mar;109(3):396-402. doi: 10.1254/jphs.08297fp. Epub 2009 Mar 7. PMID: 19270432.

3: Ago Y, Nakamura S, Hayashi A, Itoh S, Baba A, Matsuda T. Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice. Pharmacol Biochem Behav. 2006 Sep;85(1):198-205. doi: 10.1016/j.pbb.2006.07.036. Epub 2006 Sep 8. PMID: 16962650.

4: Ago Y, Nakamura S, Uda M, Kajii Y, Abe M, Baba A, Matsuda T. Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice. Neuropharmacology. 2006 Sep;51(4):914-22. doi: 10.1016/j.neuropharm.2006.06.001. Epub 2006 Jul 24. PMID: 16863654.

5: Tsuchida R, Kubo M, Shintani N, Abe M, Köves K, Uetsuki K, Kuroda M, Hashimoto H, Baba A. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31. doi: 10.1248/bpb.32.728. PMID: 19336914.

6: Ago Y, Nakamura S, Baba A, Matsuda T. Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine- and cocaine-induced behavioral sensitization in mice. J Pharmacol Sci. 2008 Jan;106(1):15-21. doi: 10.1254/jphs.fm0070121. Epub 2008 Jan 16. PMID: 18198473.

7: Hiramatsu N, Ago Y, Hasebe S, Nishimura A, Mori K, Takuma K, Matsuda T. Synergistic effect of 5-HT1A and σ1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency. Neuropharmacology. 2013 Dec;75:53-61. doi: 10.1016/j.neuropharm.2013.06.026. Epub 2013 Jul 9. PMID: 23851260.

8: Ago Y, Hasebe S, Hiramatsu N, Mori K, Watabe Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T. Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency. Psychopharmacology (Berl). 2016 Sep;233(17):3125-34. doi: 10.1007/s00213-016-4353-3. Epub 2016 Jun 23. PMID: 27339616.

9: Tanaka T, Ago Y, Umehara C, Imoto E, Hasebe S, Hashimoto H, Takuma K, Matsuda T. Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice. Int J Neuropsychopharmacol. 2017 May 1;20(5):410-421. doi: 10.1093/ijnp/pyw115. PMID: 28034961; PMCID: PMC5417057.

10: Nakamura S, Ago Y, Hayashi A, Itoh S, Kakuda M, Hashimoto H, Baba A, Matsuda T. Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice. Synapse. 2006 Dec 1;60(7):479-84. doi: 10.1002/syn.20323. PMID: 16952156.