WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510328
CAS#: 556813-39-9
Description: CHIR98014, also known as CT-98024, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
MedKoo Cat#: 510328
Name: CHIR98014
CAS#: 556813-39-9
Chemical Formula: C20H17Cl2N9O2
Exact Mass: 485.08823
Molecular Weight: 486.31
Elemental Analysis: C, 49.39; H, 3.52; Cl, 14.58; N, 25.92; O, 6.58
CHIR98014 free base, purity > 98%, is in stock. The same day shipping out after order is received.
Related CAS #: 556813-39-9 252935-94-7
Synonym: CHIR98014; CHIR-98014; CHIR 98014; CT 98024; CT-98024; CT98024;
IUPAC/Chemical Name: N2-(2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine
InChi Key: NDFXSHIIGXVOKT-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H17Cl2N9O2/c21-11-1-2-12(14(22)9-11)17-13(19-25-6-7-26-19)10-28-20(30-17)27-8-5-24-16-4-3-15(31(32)33)18(23)29-16/h1-4,6-7,9-10H,5,8H2,(H,25,26)(H3,23,24,29)(H,27,28,30)
SMILES Code: NC1=NC(NCCNC2=NC=C(C3=NC=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)=CC=C1[N+]([O-])=O
The following data is based on the product molecular weight 486.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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