WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510328
CAS#: 556813-39-9
Description: CHIR98014, also known as CT-98024, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
MedKoo Cat#: 510328
Name: CHIR98014
CAS#: 556813-39-9
Chemical Formula: C20H17Cl2N9O2
Exact Mass: 485.08823
Molecular Weight: 486.31
Elemental Analysis: C, 49.39; H, 3.52; Cl, 14.58; N, 25.92; O, 6.58
Related CAS #: 556813-39-9 252935-94-7
Synonym: CHIR98014; CHIR-98014; CHIR 98014; CT 98024; CT-98024; CT98024;
IUPAC/Chemical Name: N2-(2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine
InChi Key: NDFXSHIIGXVOKT-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H17Cl2N9O2/c21-11-1-2-12(14(22)9-11)17-13(19-25-6-7-26-19)10-28-20(30-17)27-8-5-24-16-4-3-15(31(32)33)18(23)29-16/h1-4,6-7,9-10H,5,8H2,(H,25,26)(H3,23,24,29)(H,27,28,30)
SMILES Code: NC1=NC(NCCNC2=NC=C(C3=NC=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)=CC=C1[N+]([O-])=O
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