NSC23766 3HCl salt
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MedKoo CAT#: 510327

CAS#: 1177865-17-6 (HCl)

Description: NSC23766 is a potent Rac1 inhibitor. NSC23766 disrupted polar secretion of adhesive, polarization of endomembranes, and tip-focused growth in the rhizoid. NSC23766 can acts as a competitive antagonist at muscarinic acetylcholine receptors. NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity. NSC23766 suppresses CREB signaling by targeting NMDA receptor function.


Chemical Structure

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NSC23766 3HCl salt
CAS# 1177865-17-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 510327
Name: NSC23766 3HCl salt
CAS#: 1177865-17-6 (HCl)
Chemical Formula: C24H35N7
Exact Mass:
Molecular Weight: 421.58
Elemental Analysis:

Size Price Shipping out time Quantity
50mg USD 450 2 Weeks
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1850 2 Weeks
1g USD 3250 2 Weeks
2g USD 5850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-25. Prices are subject to change without notice.

NSC23766 3HCl, purity > 98%, is in stock.

Related CAS #: 733767-34-5 (free base)   1177865-17-6 (HCl)    

Synonym: NSC23766; NSC23766; NSC 23766; NSC23766 3HCl salt; NSC23766 trihydrochloride; NSC23766 hydrochloride.

IUPAC/Chemical Name: N6-(2-((5-(diethylamino)pentan-2-yl)amino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine trihydrochloride

InChi Key: CPUHORIUXPQCHW-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H

SMILES Code: NC1=CC(C)=NC2=CC=C(NC3=NC(NC(CCCN(CC)CC)C)=NC(C)=C3)C=C12.[H]Cl.[H]Cl.[H]Cl

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 421.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hou H, Chávez AE, Wang CC, Yang H, Gu H, Siddoway BA, Hall BJ, Castillo PE, Xia H. The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function. J Neurosci. 2014 Oct 15;34(42):14006-12. doi: 10.1523/JNEUROSCI.1659-14.2014. PubMed PMID: 25319697; PubMed Central PMCID: PMC4198541.

2: Zhu S, Chen P, Wu Y, Xiong S, Sun H, Xia Q, Shi L, Liu H, Ouyang HW. Programmed Application of Transforming Growth Factor β3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair. Stem Cells Transl Med. 2014 Oct;3(10):1242-51. doi: 10.5966/sctm.2014-0042. Epub 2014 Aug 25. PubMed PMID: 25154784; PubMed Central PMCID: PMC4181399.

3: Liao J, Ye Z, Huang G, Xu C, Guo Q, Wang E. Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation. Neuropharmacology. 2014 Oct;85:508-16. doi: 10.1016/j.neuropharm.2014.06.008. Epub 2014 Jun 20. PubMed PMID: 24953831.

4: Dierkes R, Warnking K, Liedmann S, Seyer R, Ludwig S, Ehrhardt C. The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity. PLoS One. 2014 Feb 11;9(2):e88520. doi: 10.1371/journal.pone.0088520. eCollection 2014. PubMed PMID: 24523909; PubMed Central PMCID: PMC3921225.

5: Zhu S, Lu P, Liu H, Chen P, Wu Y, Wang Y, Sun H, Zhang X, Xia Q, Heng BC, Zhou Y, Ouyang HW. Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo. Ann Rheum Dis. 2015 Jan;74(1):285-93. doi: 10.1136/annrheumdis-2013-203901. Epub 2013 Nov 20. PubMed PMID: 24257023.

6: Levay M, Krobert KA, Wittig K, Voigt N, Bermudez M, Wolber G, Dobrev D, Levy FO, Wieland T. NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors. J Pharmacol Exp Ther. 2013 Oct;347(1):69-79. doi: 10.1124/jpet.113.207266. Epub 2013 Jul 25. PubMed PMID: 23887096.

7: Milsom MD, Lee AW, Zheng Y, Cancelas JA. Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. Haematologica. 2009 Jul;94(7):1011-5. doi: 10.3324/haematol.2008.004077. Epub 2009 Jun 2. PubMed PMID: 19491337; PubMed Central PMCID: PMC2704313.

8: Hable WE, Reddy S, Julien L. The Rac1 inhibitor, NSC23766, depolarizes adhesive secretion, endomembrane cycling, and tip growth in the fucoid alga, Silvetia compressa. Planta. 2008 Apr;227(5):991-1000. doi: 10.1007/s00425-007-0673-1. Epub 2008 Jan 9. PubMed PMID: 18183417.



Additional Information

Related CAS#
1177865-17-6 (NSC23766·3HCl),
733767-34-5 (NSC23766 free base)