WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 414594
CAS#: 2779-55-7
Description: Opiniazide was used for the treatment of meningeal tuberculosis in adults and in children.
MedKoo Cat#: 414594
Name: Opiniazide
CAS#: 2779-55-7
Chemical Formula: C16H15N3O5
Exact Mass: 329.1012
Molecular Weight: 329.31
Elemental Analysis: C, 58.36; H, 4.59; N, 12.76; O, 24.29
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Synonym: Opiniazide; BRN0319537; BRN-0319537; BRN 0319537
IUPAC/Chemical Name: 1-(2-Carboxy-3,4-dimethoxybenzylidene)-2-isonicotinoylhydrazine
InChi Key: HSYFNANHKYNZNI-GIJQJNRQSA-N
InChi Code: InChI=1S/C16H15N3O5/c1-23-12-4-3-11(13(16(21)22)14(12)24-2)9-18-19-15(20)10-5-7-17-8-6-10/h3-9H,1-2H3,(H,19,20)(H,21,22)/b18-9+
SMILES Code: O=C(N/N=C/C1=CC=C(OC)C(OC)=C1C(O)=O)C2=CC=NC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 329.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Sadovnikov AA. Vnutrilegochnye instilliatsii pri destruktivnom tuberkuleze [Intrapulmonary instillations in destructive tuberculosis]. Grud Serdechnososudistaia Khir. 1993 May-Jun;(3):40-2. Russian. PMID: 8217316.
2: TOKAREVA BA. Lechenie saliuzidom tuberkuleznykh porazhenii glaz [Treatment of ocular tuberculosis with saluzid]. Probl Tuberk. 1957;35(6):55-60. Russian. PMID: 13505780.
3: Mozhenok TP, Solov'eva LV, Braun AD, Bulychev AG. Vliianie razlichnykh protivotuberkuleznykh sredstv na sliianie fagosom s lizosomami, na soderzhanie F-aktina v peritoneal'nykh makrofagakh myshi i na polimerizatsiiu G-aktina in vitro] [The effect of different antitubercular agents on phagosome fusion with lysosomes, on the F-actin content in mouse peritoneal macrophages and on G-actin polymerization in vitro]. Tsitologiia. 1994;36(11):1123-8. Russian. Erratum in: Tsitologiia 1995;37(3):following 282. PMID: 7709472.
4: GABER Ie. O vliianii saliuzida na refleksy s interotseptorov [Effect of saluzid on reflexes from interoceptors]. Biull Eksp Biol Med. 1956 Sep;42(9):25-7. Russian. PMID: 13382949.
5: KHUDZIK LB. O DE ISTVII SALIUZIDA NA ZHIVOTNY I ORGANIZM [ON THE EFFECT OF SALUZID ON THE ANIMAL ORGANISM]. Probl Tuberk. 1964;42:77-9. Russian. PMID: 14175077.
6: BERNSHTEIN AL, KRASILSHCHIK RB, SHELAGUROVA AA. Nabliudeniia po lecheniiu tuberkuleznogo meningita saliuzidom [Observations on the treatment of tuberculous meningitis with saluzide]. Klin Med (Mosk). 1956 Jul;34(7):55-60. Russian. PMID: 13368366.
7: ABRAMSON ES. Saliuzid v terapii tuberkuleznogo meningita u detei [Saluzid in the treatment of meningeal tuberculosis in children]. Probl Tuberk. 1958;36(3):53-7. Russian. PMID: 13554373.
8: SOLDATOV VE. Saliuzid v lechenii tuberkuleznogo meningita u vzroslykh [Saluzide in the treatment of tuberculous meningitis in adults]. Probl Tuberk. 1955 Nov-Dec;(6):16-21. Russian. PMID: 13289818.
9: SHCHEPETIL'NIKOVA OG. [A study of the effect of saluzid on the metabolism of phosphorus compounds in the liver during experimental tuberculosis with the aid of radioactive phosphorus]. Probl Tuberk. 1962;40(2):83-91. Russian. PMID: 13911498.
10: VOZNESENSKII AN. Opyt lecheniia saliuzidom bol'nykh tuberkulezom organov dykhaniia [Experience in treating respiratory tract tuberculosis with saluzid]. Vestn Otorinolaringol. 1956 Sep-Oct;18(5):53-7. Russian. PMID: 13392346.
