OPC-14117 2HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414592

CAS#: 103247-40-1 (2HCl)

Description: OPC-14117 2HCl is an antioxidant that has both brain function activating effect and protective effect against cerebral ischemia.

Chemical Structure

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OPC-14117 2HCl
CAS# 103247-40-1 (2HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 414592
Name: OPC-14117 2HCl
CAS#: 103247-40-1 (2HCl)
Chemical Formula: C26H37Cl2N3O3
Exact Mass: 509.22
Molecular Weight: 510.500
Elemental Analysis: C, 61.17; H, 7.31; Cl, 13.89; N, 8.23; O, 9.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 103247-40-1 (2HCl); 103233-65-4 (free base)  

Synonym: OPC-14117 dihydrochloride; OPC-14117 2HCl; OPC-14117-dihcl; OPC14117-dihcl; OPC 14117-dihcl; OPC14117 2HCl; OPC 14117 2HCl; OPC-14117 2HCl

IUPAC/Chemical Name: 1-Piperazineacetamide, N-(2,3-dihydro-7-hydroxy-2,2,4,6-tetramethyl-1H-inden-1-yl)-4-(3-methoxyphenyl)-, hydrochloride (1:2)

InChi Key: FJPBWCKDHZPVFB-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H35N3O3.2ClH/c1-17-13-18(2)24(31)23-21(17)15-26(3,4)25(23)27-22(30)16-28-9-11-29(12-10-28)19-7-6-8-20(14-19)32-5;;/h6-8,13-14,25,31H,9-12,15-16H2,1-5H3,(H,27,30);2*1H

SMILES Code: O=C(NC1C(C)(C)CC2=C1C(O)=C(C)C=C2C)CN3CCN(C4=CC=CC(OC)=C4)CC3.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 510.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nakai M, Qin ZH, Wang Y, Chase TN. Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-kappaB activation and apoptosis in rat striatum. Brain Res Mol Brain Res. 1999 Jan 22;64(1):59-68. PubMed PMID: 9889320.

2: Aoyama N, Katayama Y, Kawamata T, Maeda T, Mori T, Yamamoto T, Kikuchi T, Uwahodo Y. Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat. Brain Res. 2002 May 3;934(2):117-24. PubMed PMID: 11955474.

3: Jinno J, Mori H, Oshiro Y, Kikuchi T, Sakurai H. Evaluation of superoxide scavenging activity of OPC-14117 by electron spin resonance technique. Free Radic Res Commun. 1991;15(4):223-30. PubMed PMID: 1667773.

4: Fisher M, Arpano MM. Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117. J Neurol Sci. 1992 May;109(1):107-10. PubMed PMID: 1517759.

5: Abe K, Morita S, Kikuchi T, Itoyama Y. Protective effect of a novel free radical scavenger, OPC-14117, on wobbler mouse motor neuron disease. J Neurosci Res. 1997 Apr 1;48(1):63-70. PubMed PMID: 9086182.

6: Nakai M, Qin Z, Wang Y, Chase TN. NMDA and non-NMDA receptor-stimulated IkappaB-alpha degradation: differential effects of the caspase-3 inhibitor DEVD.CHO, ethanol and free radical scavenger OPC-14117. Brain Res. 2000 Mar 24;859(2):207-16. PubMed PMID: 10719066.

7: Kawamata T, Katayama Y, Maeda T, Mori T, Aoyama N, Kikuchi T, Uwahodo Y. Antioxidant, OPC-14117, attenuates edema formation and behavioral deficits following cortical contusion in rats. Acta Neurochir Suppl. 1997;70:191-3. PubMed PMID: 9416319.

8: Mori T, Kawamata T, Katayama Y, Maeda T, Aoyama N, Kikuchi T, Uwahodo Y. Antioxidant, OPC-14117, attenuates edema formation, and subsequent tissue damage following cortical contusion in rats. Acta Neurochir Suppl. 1998;71:120-2. PubMed PMID: 9779162.

9: Safety and tolerability of the free-radical scavenger OPC-14117 in Huntington's disease. The Huntington Study Group. Neurology. 1998 May;50(5):1366-73. PubMed PMID: 9595988.

10: OPC 14117. Drugs R D. 1999 Jan;1(1):34-5. PubMed PMID: 10565980.

11: Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. Neurology. 1997 Jul;49(1):142-6. PubMed PMID: 9222182.

12: Otsubo K. [Studies on the efficient syntheses of the drug metabolites]. Yakugaku Zasshi. 2000 Nov;120(11):1135-47. Review. Japanese. PubMed PMID: 11190199.

13: Blanchet PJ, Konitsiotis S, Hyland K, Arnold LA, Pettigrew KD, Chase TN. Chronic exposure to MPTP as a primate model of progressive parkinsonism: a pilot study with a free radical scavenger. Exp Neurol. 1998 Oct;153(2):214-22. PubMed PMID: 9784281.

14: Oshiro Y, Sakurai Y, Tanaka T, Kikuchi T, Hirose T, Tottori K. Novel cerebroprotective agents with central nervous system stimulating activity. 2. Synthesis and pharmacology of the 1-(acylamino)-7-hydroxyindan derivatives. J Med Chem. 1991 Jul;34(7):2014-23. PubMed PMID: 1676757.

15: Vitamin E drug. Treat Rev. 1995 May;(no 18):1. PubMed PMID: 11362588.