WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 414579
CAS#: 2040964-58-5
Description: ONL-1204 is a small molecule, CD95 antigen inhibitor (Fas inhibitor) being developed by ONL Therapeutics for the treatment of retinal detachment.
MedKoo Cat#: 414579
Name: ONL-1204
CAS#: 2040964-58-5
Chemical Formula: C71H100N18O16
Exact Mass: 1460.7565
Molecular Weight: 1461.69
Elemental Analysis: C, 58.34; H, 6.90; N, 17.25; O, 17.51
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Synonym: ONL-1204; ONL1204; ONL 1204
IUPAC/Chemical Name: (S)-2-((2S,5S,11S,14S,17S,20S,23S)-20-((1H-imidazol-4-yl)methyl)-23-amino-17-((S)-sec-butyl)-14-(4-hydroxybenzyl)-24-(1H-imidazol-4-yl)-11-isobutyl-2-isopropyl-5-methyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-N1-((S)-1-(((2S,3S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)succinamide
InChi Key: MDQMJABKOUZYGG-QZJYLVOGSA-N
InChi Code: InChI=1S/C71H100N18O16/c1-10-38(7)59(70(104)81-50(61(74)95)25-41-12-18-46(90)19-13-41)88-67(101)53(27-43-16-22-48(92)23-17-43)84-66(100)55(30-56(73)93)86-69(103)58(37(5)6)87-62(96)40(9)80-57(94)33-77-64(98)51(24-36(3)4)83-65(99)52(26-42-14-20-47(91)21-15-42)85-71(105)60(39(8)11-2)89-68(102)54(29-45-32-76-35-79-45)82-63(97)49(72)28-44-31-75-34-78-44/h12-23,31-32,34-40,49-55,58-60,90-92H,10-11,24-30,33,72H2,1-9H3,(H2,73,93)(H2,74,95)(H,75,78)(H,76,79)(H,77,98)(H,80,94)(H,81,104)(H,82,97)(H,83,99)(H,84,100)(H,85,105)(H,86,103)(H,87,96)(H,88,101)(H,89,102)/t38-,39-,40-,49-,50-,51-,52-,53-,54-,55-,58-,59-,60-/m0/s1
SMILES Code: CC[C@@H]([C@@H](C(N[C@H](C(N)=O)Cc1ccc(O)cc1)=O)NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)NC([C@@H](NC([C@H](Cc2nc[nH]c2)N)=O)Cc3nc[nH]c3)=O)=O)Cc4ccc(O)cc4)=O)CC(C)C)=O)=O)C)=O)=O)CC(N)=O)=O)Cc5ccc(O)cc5)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 1461.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Krishnan A, Kocab AJ, Zacks DN, Marshak-Rothstein A, Gregory-Ksander M. A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma. J Neuroinflammation. 2019 Sep 30;16(1):184. doi: 10.1186/s12974-019-1576-3. PMID: 31570110; PMCID: PMC6767653.
2: Rolle T, Ponzetto A, Malinverni L. The Role of Neuroinflammation in Glaucoma: An Update on Molecular Mechanisms and New Therapeutic Options. Front Neurol. 2021 Feb 4;11:612422. doi: 10.3389/fneur.2020.612422. PMID: 33613418; PMCID: PMC7890114.
