Omoconazole nitrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414571

CAS#: 83621-06-1 (nitrate)

Description: Omoconazole nitrate is an Antifungal


Chemical Structure

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Omoconazole nitrate
CAS# 83621-06-1 (nitrate)

Theoretical Analysis

MedKoo Cat#: 414571
Name: Omoconazole nitrate
CAS#: 83621-06-1 (nitrate)
Chemical Formula: C20H18Cl3N3O5
Exact Mass: 485.03
Molecular Weight: 486.730
Elemental Analysis: C, 49.35; H, 3.73; Cl, 21.85; N, 8.63; O, 16.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 74512-12-2 (free base)   83621-06-1 (nitrate),  

Synonym: Omoconazole nitrate; CCRIS8167; CCRIS-8167; CCRIS 8167

IUPAC/Chemical Name: 1H-Imidazole, 1-(2-(2-(4-chlorophenoxy)ethoxy)-2-(2,4-dichlorophenyl)-1-methylethenyl)-, (Z)-, mononitrate

InChi Key: BNDOPUYTWJQTOE-VSOKSMTPSA-N

InChi Code: InChI=1S/C20H17Cl3N2O2.HNO3/c1-14(25-9-8-24-13-25)20(18-7-4-16(22)12-19(18)23)27-11-10-26-17-5-2-15(21)3-6-17;2-1(3)4/h2-9,12-13H,10-11H2,1H3;(H,2,3,4)/b20-14-;

SMILES Code: C/C(N1C=CN=C1)=C(OCCOC2=CC=C(Cl)C=C2)\C3=CC=C(Cl)C=C3Cl.O[N+]([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 486.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hashiguchi T, Ryu A, Itoyama T, Uchida K, Yamaguchi H. Study of the effective dose of a topical antifungal agent, omoconazole nitrate, on the basis of percutaneous pharmacokinetics in guinea-pigs and mice. J Pharm Pharmacol. 1997 Aug;49(8):757-61. doi: 10.1111/j.2042-7158.1997.tb06107.x. PMID: 9379351.

2: Itoyama T, Uchida K, Yamaguchi H. Therapeutic effects of omoconazole nitrate on guinea-pigs experimentally infected with Trichophyton mentagrophytes. J Antimicrob Chemother. 1997 Jun;39(6):825-7. doi: 10.1093/jac/39.6.825. PMID: 9222056.

3: Fromtling RA. Overview of medically important antifungal azole derivatives. Clin Microbiol Rev. 1988 Apr;1(2):187-217. doi: 10.1128/cmr.1.2.187. PMID: 3069196; PMCID: PMC358042.

4: Itoyama T, Uchida K, Yamaguchi H, Fujita S. Therapeutic effects of omoconazole nitrate on experimental tinea pedis, an intractable dermatophytosis, in guinea-pigs. J Antimicrob Chemother. 1997 Sep;40(3):441-4. doi: 10.1093/jac/40.3.441. PMID: 9338501.

5: Nishiyama Y, Itoyama T, Yamaguchi H. Ultrastructural alterations of Candida albicans induced by a new imidazole antimycotic omoconazole nitrate. Microbiol Immunol. 1997;41(5):395-402. doi: 10.1111/j.1348-0421.1997.tb01870.x. PMID: 9194038.

6: Babazadeh-Qazijahani M, Badali H, Irannejad H, Afsarian MH, Emami S. Imidazolylchromanones containing non-benzylic oxime ethers: synthesis and molecular modeling study of new azole antifungals selective against Cryptococcus gattii. Eur J Med Chem. 2014 Apr 9;76:264-73. doi: 10.1016/j.ejmech.2014.02.019. Epub 2014 Feb 11. PMID: 24583607.

7: Uchida K, Itoyama T, Yamaguchi H. [In vitro antifungal activity of omoconazole nitrate, a novel imidazone antimycotic drug, against clinical isolates from patients with cutaneous mycosis]. Jpn J Antibiot. 1996 Aug;49(8):818-23. Japanese. PMID: 9053537.

8: Mosse M, Alric MP, Berceaux M, Fourcine N, Salhi A. Etude comparative de l'activité fongistatique in vitro de l'omoconazole et de six autres imidazolés sur les levures [Comparative study of the fungistatic activity in vitro of omoconazole and 6 other imidazoles against yeasts]. Pathol Biol (Paris). 1986 Jun;34(5 Pt 2):684-7. French. PMID: 3534768.

9: Wang L, Yang W, Wang K, Zhu J, Shen F, Hu Y. Synthesis and biological evaluation of vinyl ether-containing azole derivatives as inhibitors of Trichophyton rubrum. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4887-90. doi: 10.1016/j.bmcl.2012.05.070. Epub 2012 May 24. PMID: 22683344.

10: Zirngibl L, Fischer J, Jahn U, Thiele K. Structure-activity relationships of 2-(1H-imidazol-1-yl)vinyl ethers. Route to the new broad-spectrum antifungal agent omoconazole. Ann N Y Acad Sci. 1988;544:63-73. doi: 10.1111/j.1749-6632.1988.tb40389.x. PMID: 3214095.