WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465212
CAS#: unknown
Description: WDR5-47 is a WIN inhibitor.
MedKoo Cat#: 465212
Name: WDR5-47
CAS#: unknown
Chemical Formula: C19H20ClFN4O3
Exact Mass: 406.1208
Molecular Weight: 406.8424
Elemental Analysis: C, 56.09; H, 4.96; Cl, 8.71; F, 4.67; N, 13.77; O, 11.80
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: WDR5-47; WDR5 47; WDR547;
IUPAC/Chemical Name: 2-chloro-4-fluoro-3-methyl-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
InChi Key: QHWMIGPLLWYRIR-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H20ClFN4O3/c1-12-15(21)5-4-14(18(12)20)19(26)22-16-11-13(25(27)28)3-6-17(16)24-9-7-23(2)8-10-24/h3-6,11H,7-10H2,1-2H3,(H,22,26)
SMILES Code: O=C(C1=CC=C(F)C(C)=C1Cl)NC2=C(N3CCN(C)CC3)C=CC([N+]([O-])=O)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 406.8424 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Li DD, Chen WL, Xu XL, Jiang F, Wang L, Xie YY, Zhang XJ, Guo XK, You QD, Sun HP. Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5. Eur J Med Chem. 2016 Aug 8;118:1-8. doi: 10.1016/j.ejmech.2016.04.032. Epub 2016 Apr 13. PMID: 27116709.
