Olcorolimus

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414561

CAS#: 186752-78-3

Description: Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5

Chemical Structure

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Olcorolimus
CAS# 186752-78-3
Instruction

Theoretical Analysis

MedKoo Cat#: 414561
Name: Olcorolimus
CAS#: 186752-78-3
Chemical Formula: C51H81NO12
Exact Mass: 899.58
Molecular Weight: 900.200
Elemental Analysis: C, 68.05; H, 9.07; N, 1.56; O, 21.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Olcorolimus; SAR943; SAR943-NXA; SAR943N

IUPAC/Chemical Name: UNKNOWN

InChi Key: QFMKPDZCOKCBAQ-NFCVMBANSA-N

InChi Code: InChI=1S/C51H81NO12/c1-31-16-12-11-13-17-33(3)43(60-8)30-39-22-20-37(7)51(59,64-39)48(56)49(57)52-25-15-14-18-40(52)50(58)63-42(34(4)28-38-21-23-41(53)44(29-38)61-9)24-19-32(2)27-36(6)46(55)47(62-10)45(54)35(5)26-31/h11-13,16-17,27,31-32,34-35,37-44,46-47,53,55,59H,14-15,18-26,28-30H2,1-10H3/b13-11+,16-12+,33-17+,36-27+/t31-,32+,34-,35-,37-,38+,39+,40+,41-,42+,43+,44-,46-,47+,51-/m1/s1

SMILES Code: CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@H]([C@@H]2CC[C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@@H](OC)C[C@@H]3CC[C@H]([C@@](O3)(C(C(N4CCCC[C@H]4C(O2)=O)=O)=O)O)C)\C)C)C)=O)OC)O)\C)C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 900.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Eynott PR, Salmon M, Huang TJ, Oates T, Nicklin PL, Chung KF. Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats. Immunology. 2003 Jul;109(3):461-7. doi: 10.1046/j.1365-2567.2003.01672.x. PMID: 12807493; PMCID: PMC1782985.

2: Huang TJ, Eynott P, Salmon M, Nicklin PL, Chung KF. Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised rats. Eur J Pharmacol. 2002 Feb 22;437(3):187-94. doi: 10.1016/s0014-2999(02)01295-5. PMID: 11890908.

3: Tigani B, Hannon JP, Schaeublin E, Mazzoni L, Fozard JR. Effects of immunomodulators on airways hyperresponsiveness to adenosine induced in actively sensitised Brown Norway rats by exposure to allergen. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):17-25. doi: 10.1007/s00210-003-0767-7. Epub 2003 Jun 24. PMID: 12827216.

4: Strom T, Shokati T, Klawitter J, Klawitter J, Hoffman K, Schiebel HM, Christians U. Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. J Mass Spectrom. 2011 Jul;46(7):615-24. doi: 10.1002/jms.1930. PMID: 21671437.