WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414559

CAS#: 146510-36-3

Description: Olanexidine is an antiseptic/disinfectant compound with potent bactericidal activity against Gram-negative and Gram-positive bacteria

Chemical Structure

CAS# 146510-36-3

Theoretical Analysis

MedKoo Cat#: 414559
Name: Olanexidine
CAS#: 146510-36-3
Chemical Formula: C17H27Cl2N5
Exact Mass: 371.1644
Molecular Weight: 372.34
Elemental Analysis: C, 54.84; H, 7.31; Cl, 19.04; N, 18.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Olanexidine

IUPAC/Chemical Name: 1-(3,4-Dichlorobenzyl)-5-octylbiguanide


InChi Code: InChI=1S/C17H27Cl2N5/c1-2-3-4-5-6-7-10-22-16(20)24-17(21)23-12-13-8-9-14(18)15(19)11-13/h8-9,11H,2-7,10,12H2,1H3,(H5,20,21,22,23,24)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 372.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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Dilution Calculator

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1: Obara H, Takeuchi M, Kawakubo H, Shinoda M, Okabayashi K, Hayashi K, Sekimoto Y, Maeda Y, Kondo T, Sato Y, Kitagawa Y. Aqueous olanexidine versus aqueous povidone-iodine for surgical skin antisepsis on the incidence of surgical site infections after clean-contaminated surgery: a multicentre, prospective, blinded-endpoint, randomised controlled trial. Lancet Infect Dis. 2020 Nov;20(11):1281-1289. doi: 10.1016/S1473-3099(20)30225-5. Epub 2020 Jun 15. PMID: 32553191.

2: Willy C, Vogt D. Should olanexidine be used routinely for surgical skin antisepsis? Lancet Infect Dis. 2020 Nov;20(11):1219-1220. doi: 10.1016/S1473-3099(20)30281-4. Epub 2020 Jun 15. PMID: 32553189.

3: Imai K, Hagi A, Inoue Y, Amarasiri M, Sano D. Virucidal Efficacy of Olanexidine Gluconate as a Hand Antiseptic Against Human Norovirus. Food Environ Virol. 2020 Jun;12(2):180-190. doi: 10.1007/s12560-020-09422-4. Epub 2020 Mar 2. PMID: 32124244; PMCID: PMC7225205.

4: Asukai M, Ohishi T, Fujita T, Suzuki D, Nishida T, Sugiura K, Matsuyama Y. Olanexidine gluconate versus povidone-iodine for preventing surgical-site infection in orthopaedic surgery: A retrospective study. J Orthop Sci. 2019 Nov;24(6):1125-1129. doi: 10.1016/j.jos.2019.07.008. Epub 2019 Aug 6. PMID: 31395421.

5: Nakata H, Tsubotani Y, Nii T, Hagi A, Inoue Y, Imamura T. Effects of olanexidine gluconate on preoperative skin preparation: an experimental study in cynomolgus monkeys. J Med Microbiol. 2017 May;66(5):678-685. doi: 10.1099/jmm.0.000462. Epub 2017 May 18. PMID: 28516852; PMCID: PMC5817230.

6: Nii T, Yumoto H, Hirota K, Miyake Y. Anti-inflammatory effects of olanexidine gluconate on oral epithelial cells. BMC Oral Health. 2019 Nov 8;19(1):239. doi: 10.1186/s12903-019-0932-0. PMID: 31703580; PMCID: PMC6839112.

7: Nakaminami H, Takadama S, Okita M, Sasaki M, Noguchi N. Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus. J Med Microbiol. 2019 Jun;68(6):957-960. doi: 10.1099/jmm.0.000979. Epub 2019 May 3. PMID: 31050633.

8: Matsuoka K, Kumata S, Watanabe R, Yamada T, Matsuoka T, Nagai S, Ueda M, Miyamoto Y. Dermatitis caused by Olanedine (olanexidine gluconate) and povidone iodine. Contact Dermatitis. 2019 Apr;80(4):239-241. doi: 10.1111/cod.13178. Epub 2018 Dec 13. PMID: 30430595.

9: Hu Y, Xiao Y, Rao Z, Kumar V, Liu H, Lu C. Carbon-Carbon Bond Cleavage Catalyzed by Human Cytochrome P450 Enzymes: a-Ketol as the Key Intermediate Metabolite in Sequential Metabolism of Olanexidine. Drug Metab Lett. 2019 Nov 24. doi: 10.2174/1872312813666191125095818. Epub ahead of print. PMID: 31763971.

10: Takeuchi M, Obara H, Kawakubo H, Shinoda M, Okabayashi K, Mayanagi S, Irino T, Fukuda K, Nakamura R, Wada N, Kitago M, Yagi H, Abe Y, Oshima G, Hori S, Tsuruta M, Ishida T, Yokose T, Hirukawa K, Isobe Y, Sekimoto Y, Harada H, Maeda Y, Shito M, Kondo T, Sato Y, Kitagawa Y. Comparison of olanexidine versus povidone-iodine for preventing surgical site infection in gastrointestinal surgery: study protocol for a multicentre, single-blind, randomised controlled clinical trial. BMJ Open. 2019 May 28;9(5):e028269. doi: 10.1136/bmjopen-2018-028269. PMID: 31142533; PMCID: PMC6549615.