WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465203
Description: 10B12 is a PKC Activator. 10B12 is a DAG-lactone with an isoxazole ring, binds PKCα and PKCε with nanomolar affinity. Remarkably, 10B12 displays preferential selectivity for PKCε translocation in cells and induces a PKCε-dependent reorganization of the actin cytoskeleton into peripheral ruffles in lung cancer cells.
MedKoo Cat#: 465203
Chemical Formula: C21H33NO5
Exact Mass: 379.2359
Molecular Weight: 379.497
Elemental Analysis: C, 66.46; H, 8.77; N, 3.69; O, 21.08
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: 10B12; 10 B12; 10-B12;
IUPAC/Chemical Name: (E)-5-(hydroxymethyl)-3-(3-isobutyl-5-methylhexylidene)-5-(((5-methylisoxazol-3-yl)oxy)methyl)dihydrofuran-2(3H)-one
InChi Key: COPQMLDDHGHTAG-CNHKJKLMSA-N
InChi Code: InChI=1S/C21H33NO5/c1-14(2)8-17(9-15(3)4)6-7-18-11-21(12-23,26-20(18)24)13-25-19-10-16(5)27-22-19/h7,10,14-15,17,23H,6,8-9,11-13H2,1-5H3/b18-7+
SMILES Code: O=C1OC(COC2=NOC(C)=C2)(CO)C/C1=C\CC(CC(C)C)CC(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 379.497 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Elhalem E, Bellomo A, Cooke M, Scravaglieri A, Pearce LV, Peach ML, Gandolfi Donadío L, Kazanietz MG, Comin MJ. Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators. J Med Chem. 2021 Jul 19. doi: 10.1021/acs.jmedchem.1c00739. Epub ahead of print. PMID: 34279947.