WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 414535
CAS#: 134376-90-2
Description: OC 5186 is a prostaglandin B2 oligomeric ester with protective effects on forebrain ischemia in rats.
MedKoo Cat#: 414535
Name: OC 5186
CAS#: 134376-90-2
Chemical Formula: C26H38O10
Exact Mass: 510.2465
Molecular Weight: 510.58
Elemental Analysis: C, 61.16; H, 7.50; O, 31.33
This product is not in stock, which may be available by custom synthesis.
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Synonym: OC 5186; OC5186; OC-5186
IUPAC/Chemical Name: (Z)-7-(2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-1-en-1-yl)hept-5-enoic acid compound with (R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one (1:1)
InChi Key: PAZBJQRIQDIEQH-UBKHKVECSA-N
InChi Code: InChI=1S/C20H30O4.C6H8O6/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24;7-1-2(8)5-3(9)4(10)6(11)12-5/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24);2,5,7-10H,1H2/b7-4-,14-12+;/t17-;2-,5+/m00/s1
SMILES Code: CCCCC[C@@H](/C=C/C1=C(C(CC1)=O)C/C=C\CCCC(O)=O)O.OC[C@@H]([C@H]2OC(C(O)=C2O)=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 510.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Tokuka A, Tanaka A, Fujita T, Hayashi M, Kitai T, Yamaoka Y, Ozawa K, Ohnishi ST. Protective effect of a prostaglandin oligomer on liver mitochondria in situ: time-shared measurements of fluorescence and reflectance in the cold-preserved rat liver. Transpl Int. 1992 Sep;5(4):193-6. doi: 10.1007/BF00336068. PMID: 1418308.
2: Chandra S, Ohnishi ST, Dhawan BN. Reversal of chloroquine resistance in murine malaria parasites by prostaglandin derivatives. Am J Trop Med Hyg. 1993 May;48(5):645-51. doi: 10.4269/ajtmh.1993.48.645. PMID: 8517483.
3: Kurata M, Okuda M, Muneyuki M, Ohnishi ST. [31P]MRS study of the protective effects of prostaglandin oligomers on forebrain ischemia in rats. Brain Res. 1991 Apr 5;545(1-2):315-8. doi: 10.1016/0006-8993(91)91305-k. PMID: 1860052.
4: Sakamoto A, Ohnishi ST, Ohnishi T, Ogawa R. Protective effect of a new anti- oxidant on the rat brain exposed to ischemia-reperfusion injury: inhibition of free radical formation and lipid peroxidation. Free Radic Biol Med. 1991;11(4):385-91. doi: 10.1016/0891-5849(91)90155-v. PMID: 1665837.
5: Hidaka S, Morita N, Ohnishi ST, Oga Y, Abe K. Inhibitory effect of prostaglandin oligomeric derivatives on 9,10-dimethyl-1,2-benzanthracene-induced hamster lingual carcinomas. Cancer Lett. 1992 Jan 10;61(2):171-6. doi: 10.1016/0304-3835(92)90176-v. PMID: 1730141.
