OC 5186

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414535

CAS#: 134376-90-2

Description: OC 5186 is a prostaglandin B2 oligomeric ester with protective effects on forebrain ischemia in rats.


Chemical Structure

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OC 5186
CAS# 134376-90-2

Theoretical Analysis

MedKoo Cat#: 414535
Name: OC 5186
CAS#: 134376-90-2
Chemical Formula: C26H38O10
Exact Mass: 510.2465
Molecular Weight: 510.58
Elemental Analysis: C, 61.16; H, 7.50; O, 31.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: OC 5186; OC5186; OC-5186

IUPAC/Chemical Name: (Z)-7-(2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-1-en-1-yl)hept-5-enoic acid compound with (R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one (1:1)

InChi Key: PAZBJQRIQDIEQH-UBKHKVECSA-N

InChi Code: InChI=1S/C20H30O4.C6H8O6/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24;7-1-2(8)5-3(9)4(10)6(11)12-5/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24);2,5,7-10H,1H2/b7-4-,14-12+;/t17-;2-,5+/m00/s1

SMILES Code: CCCCC[C@@H](/C=C/C1=C(C(CC1)=O)C/C=C\CCCC(O)=O)O.OC[C@@H]([C@H]2OC(C(O)=C2O)=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 510.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Tokuka A, Tanaka A, Fujita T, Hayashi M, Kitai T, Yamaoka Y, Ozawa K, Ohnishi ST. Protective effect of a prostaglandin oligomer on liver mitochondria in situ: time-shared measurements of fluorescence and reflectance in the cold-preserved rat liver. Transpl Int. 1992 Sep;5(4):193-6. doi: 10.1007/BF00336068. PMID: 1418308.

2: Chandra S, Ohnishi ST, Dhawan BN. Reversal of chloroquine resistance in murine malaria parasites by prostaglandin derivatives. Am J Trop Med Hyg. 1993 May;48(5):645-51. doi: 10.4269/ajtmh.1993.48.645. PMID: 8517483.

3: Kurata M, Okuda M, Muneyuki M, Ohnishi ST. [31P]MRS study of the protective effects of prostaglandin oligomers on forebrain ischemia in rats. Brain Res. 1991 Apr 5;545(1-2):315-8. doi: 10.1016/0006-8993(91)91305-k. PMID: 1860052.

4: Sakamoto A, Ohnishi ST, Ohnishi T, Ogawa R. Protective effect of a new anti- oxidant on the rat brain exposed to ischemia-reperfusion injury: inhibition of free radical formation and lipid peroxidation. Free Radic Biol Med. 1991;11(4):385-91. doi: 10.1016/0891-5849(91)90155-v. PMID: 1665837.

5: Hidaka S, Morita N, Ohnishi ST, Oga Y, Abe K. Inhibitory effect of prostaglandin oligomeric derivatives on 9,10-dimethyl-1,2-benzanthracene-induced hamster lingual carcinomas. Cancer Lett. 1992 Jan 10;61(2):171-6. doi: 10.1016/0304-3835(92)90176-v. PMID: 1730141.