NPC 17761

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414511

CAS#: 147333-13-9

Description: NPC 17761 is a bradykinin receptor antagonist.

Chemical Structure

img
NPC 17761
CAS# 147333-13-9
Instruction

Theoretical Analysis

MedKoo Cat#: 414511
Name: NPC 17761
CAS#: 147333-13-9
Chemical Formula: C62H93N19O13S
Exact Mass: 1,343.69
Molecular Weight: 1,344.610
Elemental Analysis: C, 55.38; H, 6.97; N, 19.79; O, 15.47; S, 2.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NPC 17761; NPC17761; NPC-17761

IUPAC/Chemical Name: (1-(1-((1-(arginylarginylprolyl)-4-hydroxypyrrolidine-2-carbonyl)glycylphenylalanylseryl)-4-(phenylthio)pyrrolidine-2-carbonyl)octahydro-1H-indole-2-carbonyl)arginine

InChi Key: TTZWORQGJCRWCJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C62H93N19O13S/c63-40(18-9-23-70-60(64)65)51(85)75-41(19-10-24-71-61(66)67)55(89)78-26-12-22-46(78)57(91)79-32-37(83)29-47(79)53(87)73-31-50(84)74-43(27-35-13-3-1-4-14-35)52(86)77-44(34-82)56(90)80-33-39(95-38-16-5-2-6-17-38)30-49(80)58(92)81-45-21-8-7-15-36(45)28-48(81)54(88)76-42(59(93)94)20-11-25-72-62(68)69/h1-6,13-14,16-17,36-37,39-49,82-83H,7-12,15,18-34,63H2,(H,73,87)(H,74,84)(H,75,85)(H,76,88)(H,77,86)(H,93,94)(H4,64,65,70)(H4,66,67,71)(H4,68,69,72)

SMILES Code: NC(C(NC(C(N1CCCC1C(N2CC(CC2C(NCC(NC(C(NC(C(N3CC(Sc4ccccc4)CC3C(N5C6CCCCC6CC5C(NC(C(O)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)Cc7ccccc7)=O)=O)O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,344.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Otterbein L, Lowe VC, Kyle DJ, Noronha-Blob L. Additive effects of a bradykinin antagonist, NPC 17761, and a leumedin, NPC 15669, on survival in animal models of sepsis. Agents Actions. 1993;39 Spec No:C125-7. doi: 10.1007/BF01972742. PMID: 8273550.

2: Corrêa CR, Calixto JB. Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse. Br J Pharmacol. 1993 Sep;110(1):193-8. doi: 10.1111/j.1476-5381.1993.tb13791.x. PMID: 8220879; PMCID: PMC2176006.

3: Da Silva A, Amrani Y, Trifilieff A, Landry Y. Involvement of B2 receptors in the bradykinin-induced relaxation of guinea-pig isolated trachea. Br J Pharmacol. 1995 Jan;114(1):103-8. doi: 10.1111/j.1476-5381.1995.tb14912.x. PMID: 7712004; PMCID: PMC1510188.

4: Schlemper V, Calixto JB. Mechanisms involved in the relaxant response of bradykinin in epithelium intact strips of the guinea-pig trachea. Eur J Pharmacol. 1995 Aug 25;282(1-3):177-84. doi: 10.1016/0014-2999(95)00329-j. PMID: 7498273.

5: Dear JW, Wirth K, Scadding GK, Foreman JC. Characterization of the bradykinin receptor in the human nasal airway using the binding of [125I]-Hoe 140. Br J Pharmacol. 1996 Nov;119(5):1054-62. doi: 10.1111/j.1476-5381.1996.tb15777.x. PMID: 8922758; PMCID: PMC1915934.

6: Forteza R, Lauredo IT, Burch R, Abraham WM. Extracellular metabolites of Pseudomonas aeruginosa produce bronchoconstriction by different mechanisms. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):687-93. doi: 10.1164/ajrccm.149.3.8118638. PMID: 8118638.

7: Cabrini DA, Calixto JB. Characterization of des-Arg9-bradykinin-induced contraction in guinea-pig gallbladder in vitro. Eur J Pharmacol. 1997 Jul 16;331(1):31-8. doi: 10.1016/s0014-2999(97)01010-8. PMID: 9274927.

8: Trifilieff A, Amrani Y, Landry Y, Gies JP. Comparative action of new highly potent bradykinin receptor antagonists in the guinea-pig trachea. Eur J Pharmacol. 1993 Aug 3;239(1-3):227-9. doi: 10.1016/0014-2999(93)91000-d. PMID: 8223898.

9: Novotny EA, Bednar DL, Connolly MA, Connor JR, Stormann TM. Mutation of aspartate residues in the third extracellular loop of the rat B2 bradykinin receptor decreases affinity for bradykinin. Biochem Biophys Res Commun. 1994 Jun 15;201(2):523-30. doi: 10.1006/bbrc.1994.1733. PMID: 8002982.

10: Lach E, Trifilieff A, Mousli M, Landry Y, Gies JP. Bradykinin-induced contraction of guinea pig lung in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1994 Aug;350(2):201-8. doi: 10.1007/BF00241097. PMID: 7990978.